Pam Kreeger (BE postdoctoral)
Ovarian cancer is the most lethal of all gynecological cancers, with a mortality rate of nearly 60%. Currently, ovarian cancer is associated with a poor prognosis as the majority of patients are diagnosed only after the disease has spread into the abdominal cavity. Nearly 90% of ovarian tumors originate in the ovarian surface epithelium (OSE), a thin layer of cells with no known major function. Importantly, there is limited understanding of the precursor lesion and tumor progression, inhibiting the development of diagnostic tests and effective treatments.
The objective of my research is to develop quantitative models of how normal and transformed OSE behave in response to various stimuli. In particular, I seek to identify how changes to K-ras and other protein signaling pathways impact oncogenesis.