Postdoctoral positions available to investigate mis-translation of proteins as a new stress response mechanism. A central tenet of biology is the accurate flow of information from nucleic acids to proteins through the genetic code. It is commonly believed that translation deviating from the genetic code is avoided at all times. We have discovered that mammalian cells can deliberately reprogram the genetic code upon innate immune activation and chemically triggered oxidative stress. This reprogramming is regulated by fluctuating levels of reactive oxygen species (ROS) in the cell. The postdoctoral researchers will investigate how regulated mis-translation is used as a mechanism for stress response in mammalian systems.
Candidates with expertise in standard molecular biology techniques and mammalian cell cultures preferred. Candidates should not have more than three years of postdoctoral experience.
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