Papathanos:Publications

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Genetic Engineering of Populations for Insect Control

• A CRISPR-Cas9 sex-ratio distortion system for genetic control
  

Galizi R, Hammond A, Kyrou K, Taxiarchi C, Bernardini F, O'Loughlin SM, Papathanos PA, Nolan T, Windbichler N, Crisanti A.

Scientific Reports. 2016 Aug 3;6:31139. doi: 10.1038/srep31139.

• Site-specific genetic engineering of the Anopheles gambiae Y chromosome.
  

Bernardini F, Galizi R, Menichelli M, Papathanos PA, Dritsou V, Marois E, Crisanti A, Windbichler N.

PNAS. 2014 May 27;111(21):7600-5. doi: 10.1073/pnas.1404996111. Epub 2014 May 12.

• Identification of germline transcriptional regulatory elements in Aedes aegypti.
  

Akbari OS, Papathanos PA, Sandler JE, Kennedy K, Hay BA.

Scientific Reports 2014 Feb 4;4:3954. doi: 10.1038/srep03954.

• A synthetic homing endonuclease-based gene drive system in the human malaria mosquito.
  

Windbichler N, Menichelli M, Papathanos PA, Thyme SB, Li H, Ulge UY, Hovde BT, Baker D, Monnat RJ Jr, Burt A, Crisanti A.

Nature. 2011 May 12;473(7346):212-5. doi: 10.1038/nature09937. Epub 2011 Apr 20.

• Developing transgenic Anopheles mosquitoes for the sterile insect technique.
  

Nolan T, Papathanos P, Windbichler N, Magnusson K, Benton J, Catteruccia F, Crisanti A.

Genetica. 2011 Jan;139(1):33-9. doi: 10.1007/s10709-010-9482-8. Epub 2010 Sep 7. Review.

• Sex separation strategies: past experience and new approaches.
  

Papathanos PA, Bossin HC, Benedict MQ, Catteruccia F, Malcolm CA, Alphey L, Crisanti A.

Malar Journal. 2009 Nov 16;8 Suppl 2:S5. doi: 10.1186/1475-2875-8-S2-S5. Review.

• The vasa regulatory region mediates germline expression and maternal transmission of proteins in the malaria mosquito Anopheles gambiae: a versatile tool for genetic control strategies.
  

Papathanos PA, Windbichler N, Menichelli M, Burt A, Crisanti A.

BMC Molecular Biology. 2009 Jul 2;10:65. doi: 10.1186/1471-2199-10-65.

• Targeting the X chromosome during spermatogenesis induces Y chromosome transmission ratio distortion and early dominant embryo lethality in Anopheles gambiae.
  

Windbichler N, Papathanos PA, Crisanti A.

PLoS Genetics. 2008 Dec;4(12):e1000291. doi: 10.1371/journal.pgen.1000291. Epub 2008 Dec 5.

• Homing endonuclease mediated gene targeting in Anopheles gambiae cells and embryos.
  

Windbichler N, Papathanos PA, Catteruccia F, Ranson H, Burt A, Crisanti A.

Nucleic Acids Research. 2007;35(17):5922-33. Epub 2007 Aug 28.

Insect Genomics

• Radical remodeling of the Y chromosome in a recent radiation of malaria mosquitoes.
  

Hall AB, Papathanos PA, Sharma A, Cheng C, Akbari OS, Assour L, Bergman NH, Cagnetti A, Crisanti A, Dottorini T, Fiorentini E, Galizi R, Hnath J, Jiang X, Koren S, Nolan T, Radune D, Sharakhova MV, Steele A, Timoshevskiy VA, Windbichler N, Zhang S, Hahn MW, Phillippy AM, Emrich SJ, Sharakhov IV, Tu ZJ, Besansky NJ.

PNAS 2016 Apr 12;113(15):E2114-23. doi: 10.1073/pnas.1525164113. Epub 2016 Mar 29.

• A draft genome sequence of an invasive mosquito: an Italian Aedes albopictus.
  

Dritsou V, Topalis P, Windbichler N, Simoni A, Hall A, Lawson D, Hinsley M, Hughes D, Napolioni V, Crucianelli F, Deligianni E, Gasperi G, Gomulski LM, Savini G, Manni M, Scolari F, Malacrida AR, Arcà B, Ribeiro JM, Lombardo F, Saccone G, Salvemini M, Moretti R, Aprea G, Calvitti M, Picciolini M, Papathanos PA, Spaccapelo R, Favia G, Crisanti A, Louis C.

Pathogens in Global Health. 2015 Jul;109(5):207-20. doi: 10.1179/2047773215Y.0000000031. Epub 2015 Sep 14.

• Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
  

Anopheles Genome Consortium

Science. 2015 Jan 2;347(6217):1258522. doi: 10.1126/science.1258522. Epub 2014 Nov 27.

• Demasculinization of the Anopheles gambiae X chromosome
  

Magnusson K, Lycett GJ, Mendes AM, Lynd A, Papathanos PA, Crisanti A, Windbichler N.

BMC Evolutionary Biology. 2012 May 18;12:69. doi: 10.1186/1471-2148-12-69.

• Transcription regulation of sex-biased genes during ontogeny in the malaria vector Anopheles gambiae.
  

Magnusson K, Mendes AM, Windbichler N, Papathanos PA, Nolan T, Dottorini T, Rizzi E, Christophides GK, Crisanti A.

PLoS One. 2011;6(6):e21572. doi: 10.1371/journal.pone.0021572. Epub 2011 Jun 30.