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Our main interest is to better understand the cellular and molecular basis for generation and maintenance of regulatory T cells (Tregs) in the suppression of autoimmunities and/or allergies in mouse models. We have been using intravital microscopy as the starting point for the in vivo imaging of Tregs. The use of a multi-photon microscope, the development of new intravital surgical tecniques and tools, and use of animal models that develop autoimmune and allergic diseases, we are evaluating what and where the important cell-cell contacts for Tregs generation/function happen. We hope that a better comprehension of generation and function of these Tregs will be crucial for the development of new therapies against human autoimmune and allergic diseases. Our lab is located at the Unit of Cell Imaging, IGC, Portugal.
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