Peyton:Research: Difference between revisions
No edit summary |
No edit summary |
||
Line 22: | Line 22: | ||
''Dannielle Ryman and Ravitheja Yelleswaru''<br> | ''Dannielle Ryman and Ravitheja Yelleswaru''<br> | ||
Metastasis is the leading cause of fatality for women diagnosed with breast cancer. It is well known that tumor environments stiffen: palpitation remains a powerful tool for early tumor detection. More recently, this matrix stiffening event at the sites of tumors has been linked to morphological changes in the tumor itself, and it is hypothesized by us and others that these stiffness changes may contribute to single cell metastasis. However, the mechanisms by which metastatic cells sense and respond to stiffness is unclear, and it is not yet known if metastatic cells respond to stiffness cues in a unique way. We are working with Yuri Ebata and Yujie Liu from Al Crosby's lab in PSE to make novel substrates with unique presentation of stiffness arrays and mechanical length scales. We are visualizing how breast cancer cells of varying known metastatic capability sense and respond (namely, migration and mitosis) to these changes in stiffness. From there, we will identify the molecular mechanisms by which these cells have either heightened or dampened stiffness sensing, in order to develop novel druggable targets to prevent metastasis in vivo. | Metastasis is the leading cause of fatality for women diagnosed with breast cancer. It is well known that tumor environments stiffen: palpitation remains a powerful tool for early tumor detection. More recently, this matrix stiffening event at the sites of tumors has been linked to morphological changes in the tumor itself, and it is hypothesized by us and others that these stiffness changes may contribute to single cell metastasis. However, the mechanisms by which metastatic cells sense and respond to stiffness is unclear, and it is not yet known if metastatic cells respond to stiffness cues in a unique way. We are working with Yuri Ebata and Yujie Liu from Al Crosby's lab in PSE to make novel substrates with unique presentation of stiffness arrays and mechanical length scales. We are visualizing how breast cancer cells of varying known metastatic capability sense and respond (namely, migration and mitosis) to these changes in stiffness. From there, we will identify the molecular mechanisms by which these cells have either heightened or dampened stiffness sensing, in order to develop novel druggable targets to prevent metastasis in vivo. | ||
[[Image:DRyman_Screenshot.png|center|400px]] | |||
== Signaling Network-Microenvironment Crosstalk in Metastasis == | == Signaling Network-Microenvironment Crosstalk in Metastasis == |
Revision as of 16:15, 5 May 2011
Matrix Physicochemical Cues as Chemotherapeutic Protective Agents in Hepatocellular CarcinomaThuy Nguyen Inflammatory Feedback Loops in Cardiovascular DiseaseWill Herrick Stiffness Sensing as a Metastatic IndicatorCollaboration with the Al Crosby Lab at the University of Massachusetts, Polymer Science Dannielle Ryman and Ravitheja Yelleswaru Signaling Network-Microenvironment Crosstalk in MetastasisCollaboration with the Shannon Alford Lab at the University of Minnesota Erinn Dandley Anomalous Diffusion Methods to Predict 3D Stem Cell Motility in Porous ScaffoldsCollaboration with Joshua Cohen and the Lauffenburger Lab at the Massachusetts Institute of Technology Jaclyn Somadelis and Tyler Vlass |