Piperazine

• A piperidine-like compound with 2 N atoms at opposed (symmetrical) positions and a N-derived heterocyclic building block for chiral amino protected (peptide|oligo) synthesis, hence "solid phase peptide synthesis"...
• In Fmoc SPPS, an orthogonal protection reagent for (cis/trans) microwave-triggered peptide synthesis (MWPS).

See also

• Pyridine, and Piperidine
• Enamine
• Microwave-triggered peptide synthesis
• Fmoc (9-fluorenylmethyloxycarbonyl) solid phase peptide synthesis
• Mefloquine and Tetrahydroisoquinoline
• DMF

References

1. Palasek SA, Cox ZJ, and Collins JM. Limiting racemization and aspartimide formation in microwave-enhanced Fmoc solid phase peptide synthesis. J Pept Sci. 2007 Mar;13(3):143-8. DOI:10.1002/psc.804 |