Prince:Intro to Mass Spectrometry Proteomics: Difference between revisions

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* [http://jcb.rupress.org/content/190/4/491.full.pdf+html Mass spectrometry–based proteomics in cell biology] - review by Walther & Mann
* [http://jcb.rupress.org/content/190/4/491.full.pdf+html Mass spectrometry–based proteomics in cell biology] - review by Walther & Mann
* [http://www.springerlink.com/content/978-1-60761-443-2/ Proteome Bioinformatics] -  book published in 2010, free pdfs available
* [http://www.springerlink.com/content/978-1-60761-443-2/ Proteome Bioinformatics] -  book published in 2010, free pdfs available [BYU subscription].
* [http://www.springerlink.com/content/978-1-60761-976-5/ Bioinformatics for Comparative Proteomics] -  book published in 2010, free pdfs available [BYU subscription].
* [http://www.springerlink.com/content/t2854lww4371m213/#section=864259&page=1 Bioinformatics for Qualitative and Quantitative Proteomics] (chapter 15 of Bioinformatics for Omics Data)
* [http://www.annualreviews.org/doi/abs/10.1146/annurev-bioeng-061008-124934 Proteomics by Mass Spectrometry: Approaches, Advances, and Applications] (Yates, Ruse, and Nakorchevsky)
* [http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1002277 Vitek and Kall overview of computation mass spec proteomics]
* Matlab has a series of tutorials that are useful ('''>>doc help''' then search for '''Mass Spectrometry''')


===Relevant Hype===
===Misc===


* [http://www.ncbi.nlm.nih.gov/pubmed/17031796 Comments on standards in proteomics and the concept of fitness-for-purpose] - includes discussion of hypothesis driven and exploratory research.
===Statistics of Quantitative Proteomics===
* [http://www.ncbi.nlm.nih.gov/pubmed/17893850 Design and analysis issues in quantitative proteomics studies] Simple discussion of things like 'power', 'effect size' and multiple hypothesis testing.
===Hype===
* Yates, Ruse, and Nakorchevsky ([http://www.annualreviews.org/doi/abs/10.1146/annurev-bioeng-061008-124934 see review above])
    "Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale proteomics"
* [http://archive.sciencewatch.com/march-april2007/sw_march-april2007_page3.htm Interview with Matthias Mann] (2007)
* [http://archive.sciencewatch.com/march-april2007/sw_march-april2007_page3.htm Interview with Matthias Mann] (2007)
    Q: Where do you see mass spectrometry taking the field of proteomics in the next 5 years?
* [http://www.annualreviews.org/doi/abs/10.1146/annurev-bioeng-061008-124934 Can Proteomics Retire the Western Blot?] (commentary by M. Mann)
      A: The future is now limitless … we can read out the proteome in a quantitative way, in a large-scale fashion…
        We not only want to know what proteins are present in a sample, but also how they're modified…
    Q: Are there other applications we should keep our eyes out for?
      A: … new field called "interaction proteomics" … see which proteins talk to which other proteins.

Latest revision as of 12:37, 8 July 2013

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Here are some introductory resources to the field of Mass Spectrometry Proteomics. Add more as you come across them.

Misc

Statistics of Quantitative Proteomics

Hype

   "Mass spectrometry (MS) is the most comprehensive and versatile tool in large-scale proteomics"
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