Protein-protein interaction databases

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Name Description Link
String Image:3stars.png database of experimental and predicted interactions http://string-db.org/
IntAct Image:2stars.png interactions derived from literature curation or direct user submissions http://www.ebi.ac.uk/intact/
MIPS Image:0stars.png Mammalian Protein-Protein Interaction Database (didn't work when tested in Sept '11) http://mips.helmholtz-muenchen.de/proj/ppi/
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String

  • collects evidence from genomic Context, high-throughput experiments, conserved coexpression, and text mining
  • created by CPR, EMBL, SIB, KU, TUD, and UZH
  • latest references: [1], [2]

Opinion: easy to use, great graphical interaction map, detailed explanation of evidence

IntAct

Opinion: The default is an oversized results table (>2 screen widths on a 13"). Use "Change table presets" to compact. Separate columns for links/alias/pubID could be integrated or hover over to make the default table easier on the eye. Overall, the presentation of results seems to be more geared towards bioinformaticians than users with the table full of codes instead of names (Do you know what 9606 is?). Also, no easy species selection and, more importantly, no graphical overview.

See also

On OpenWetWare

  • The Prince lab present on OWW works on protein-protein interactions.
  • OWW's Keating lab also works on protein-protein interactions.

List of protein interaction resources:

Related literature searches

  • search PubMed for MeSH term Protein Interaction Mapping [3], major topic [4], and reviews only [5]

Recent reviews:

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