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| <div style="padding: 20px; color: #ffffff; background-color: mediumBlue; width: 900px">
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| <center><font face="lucida fax" style= "color:Yellow" size="+10">'''Qianben Wang Laboratory'''</font> | | <center><font face="lucida fax" style= "color:Blue" size="+10">'''Qianben Wang Laboratory'''</font> |
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| <center><font face="lucida fax" style= "color:Yellow" size="+2">'''Laboratory of Cancer Epigenomics'''</font></center> | | <center> [https://sites.duke.edu/qianbenwanglab/<font face="lucida fax" style= "color:Blue" size="+6">'''We moved to Duke University!!!'''] |
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| <center><font face="lucida fax" style= "color:Yellow" size="+1">'''Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University'''</font>
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| <br> | | <br> |
| [[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]]
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| [[Wang:Research | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Research''' </font>]]
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| [[Wang:Publications | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Publications''' </font>]]
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| [[Wang:Lab Members | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Lab Members''' </font>]]
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| [[Wang:Contact | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Contact''' </font>]]
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| [[Wang:News | <font face="lucida fax" style="color:#ffffff" size="+1"> '''News''' </font>]]
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| [[Wang:Gallery | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Gallery''' </font>]]
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| [[Image:exo.tif]]
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| <div style="text-align:left" font face="lucia fax">'''The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.
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