Qianben Wang Laboratory: Difference between revisions
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<div style="padding: 20px; color: #ffffff; background-color: mediumBlue; width: 900px"> | |||
<div style="padding: | <center><font face="lucida fax" style= "color:Yellow" size="+10">'''Qianben Wang Laboratory'''</font> | ||
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[[Wang | <font face=" | <center><font face="lucida fax" style= "color:Yellow" size="+2">'''Laboratory of Cancer Epigenomics'''</font></center> | ||
[[Wang: | <br> | ||
[[Wang: | <center><font face="lucida fax" style= "color:Yellow" size="+1">'''Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University'''</font> | ||
[[Wang:Lab Members | <font face=" | <br> | ||
[[Wang: | [[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]] | ||
[[Wang: | [[Wang:Research | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Research''' </font>]] | ||
[[Wang: | [[Wang:Publications | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Publications''' </font>]] | ||
[[Wang:Lab Members | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Lab Members''' </font>]] | |||
[[Wang:Contact | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Contact''' </font>]] | |||
[[Wang:News | <font face="lucida fax" style="color:#ffffff" size="+1"> '''News''' </font>]] | |||
[[Wang:Gallery | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Gallery''' </font>]] | |||
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<div style="text-align:left" font face="lucia fax">'''The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively. | |||
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Revision as of 14:11, 23 December 2014
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The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.
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