Qianben Wang Laboratory: Difference between revisions

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<center><font face="lucida fax" style= "color:Crimson" size="+10">'''Qianben Wang Laboratory'''</font>
<center><font face="lucida fax" style= "color:Yellow" size="+10">'''Qianben Wang Laboratory'''</font>
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<center><font face="lucida fax" style= "color:Crimson" size="+2">'''Laboratory of Cancer Epigenomics'''</font></center>
<center><font face="lucida fax" style= "color:Yellow" size="+2">'''Laboratory of Cancer Epigenomics'''</font></center>
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<center><font face="lucida fax" style= "color:Crimson" size="+1">'''Department of Molecular and Cellular Biochemistry, The Ohio State University'''</font>
<center><font face="lucida fax" style= "color:Yellow" size="+1">'''Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University'''</font>
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[[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
[[Wang | <font face="lucida fax" style="color:#ffffff" size="+1"> '''Home''' </font>]] &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;
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[[Image:Wanglab 7.12.10 500px IMG 0018.jpg|right]] [[Image:DOD 2 FigurebyZhong.jpg]]
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<div style="text-align:left" font face="lucia fax">'''A histone modification governs androgen receptor to bind to regulatory regions of a class of cell cycle genes in castration-resistant prostate cancer but not in androgen-dependent prostate cancer. This leads to over-expression of cell cycle genes and accelerated growth of castration resistant prostate cancer.  
<div style="text-align:left" font face="lucia fax">'''The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.  
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Revision as of 14:11, 23 December 2014

Qianben Wang Laboratory


Laboratory of Cancer Epigenomics


Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University


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The schematic diagram of androgen receptor binding element (ARBE)-directed AR transcriptional regulation. Upper panel shows that agonist-bound AR (red) recognizes an agonist-ARBE in an agonist-specific manner, whereas the bottom panel indicates that antagonist-bound AR (blue) binds to an antagonist-ARBE in an antagonist-dependent manner. The binding of AR to two distinctly different motifs leads to distinct transcriptional outcomes in prostate cancer. The crystal structures of the DNA binding domain (DBD), dihydrotestosterone-ligand binding domain (DHT-LBD) and bicalutamide-LBD are modified from 1R4I, 1T7T and 1Z95, respectively.
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