Qianben Wang Laboratory

Qianben Wang Laboratory

Laboratory of Cancer Epigenomics

Department of Molecular and Cellular Biochemistry, The Ohio State University

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A histone modification governs androgen receptor to bind to regulatory regions of a class of cell cycle genes in castration-resistant prostate cancer but not in androgen-dependent prostate cancer. This leads to over-expression of cell cycle genes and accelerated growth of castration resistant prostate cancer.