Quint Lab:Research
broad research scopeHOW do organisms adapt to the environment and how do they react to different biotic and abiotic stimuli? Secondly, we are fascinated by the mechanisms of molecular evolution and how they shape plant life. Learning about the evolutionary history of signaling pathways may help to further our understanding of important developmental processes regulated by these signaling cascades.
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natural variation and quantitative genetics of hormone responsesquantitative genetics
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TIR1-dependent auxin signalingto identify novel components of SCF complex regulation and/or auxin signaling we used the f-box protein and auxin receptor mutant tir1-1 for a second site forward genetic screen. in a previous screen in bill gray's lab several enhancers of tir1-1-mediated auxin resistance had been identified (see zhang et al., pnas 2008; ito and gray, plant physiology 2006; quint et al., plant journal 2005; chuang et al., plant cell 2004; gray et al., plant cell 2003). Vice versa, we are screening for suppressors of the root growth defect on auxin-supplemented (2,4-D, artificial auxin) media. we identified appr. 15 independent tir1-1 suppressor (tis) mutants that restored the wild-type response and are currently cloning the underlying gene/s and charactarize the physiological and genetic features of the mutants. |
evo-devofor one, we are interested in the evolutionary history of gene families that are involved in important signaling cascades, such as the ubiquitin-proteasome system (see schumann et al. plant physiology 2011). furthermore, we are developing ways to utilize whole genome transcriptional information for evolutionary approaches in close collaboration with the lab of ivo grosse. By applying phylotranscriptomics – the combination of phylogenetics and transcriptomics – to developmental series such as embryogenesis, we are able to trace the evolutionary path across a complete developmental process. |