Raj Lab:Reading list

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Here's a list of papers that we think are interesting or useful (still very much a work in progress...):

Introduction to stochastic effects in gene expression

  1. Ko MS, Nakauchi H, and Takahashi N. . pmid:2167833. PubMed HubMed [ko-emboj-90]
    A surprisingly modern analysis of non-genetic variability in gene expression in mammalian cells.

  2. Elowitz MB, Levine AJ, Siggia ED, and Swain PS. . pmid:12183631. PubMed HubMed [elowitz-science-02]
    A beautiful demonstration that variability in gene expression is intrinsically random.

  3. Ozbudak EM, Thattai M, Kurtser I, Grossman AD, and van Oudenaarden A. . pmid:11967532. PubMed HubMed [ozbudak-natgen-02]
    Perhaps the first demonstration of the dependence of variability upon biochemical parameters.

All Medline abstracts: PubMed HubMed

Developmental biology

  1. Berg HC and Purcell EM. . pmid:911982. PubMed HubMed [berg-biophysj-77]
    A classic paper about the physical limits of receptor function.

  2. Gregor T, Tank DW, Wieschaus EF, and Bialek W. . pmid:17632062. PubMed HubMed [gregor-cell-07]
  3. Wernet MF, Mazzoni EO, Celik A, Duncan DM, Duncan I, and Desplan C. . pmid:16525464. PubMed HubMed [wernet-nature06]
    A technical tour de force in which the authors show that stochastic expression established the retinal mosaic in fruit flies.

  4. Chang HH, Hemberg M, Barahona M, Ingber DE, and Huang S. . pmid:18497826. PubMed HubMed [chang-nature08]
    In this paper, the authors show that stochastic lineage commitment is a result of transcriptome wide variability in gene expression. Cool!

All Medline abstracts: PubMed HubMed
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