Rao:Projects: Difference between revisions
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We are investigating chemotaxis in the model Gram-positive bacterium ''Bacillus subtilis''. While ''Escherichia coli'' has long been the paradigm for bacterial chemotaxis, the pathway architecture is not conserved in other species of bacteria. Interestingly, ''B. subtilis'' behaves in an identical manner to ''E. coli'' with regards to chemotaxis. The pathways in the two bacteria also have homologous proteins. Yet, how these proteins are “wired” to one another in the two pathways is entirely different. We seek to understand why these two pathways are “wired” differently and the extent of degeneracy in the basic design. | We are investigating chemotaxis in the model Gram-positive bacterium ''Bacillus subtilis''. While ''Escherichia coli'' has long been the paradigm for bacterial chemotaxis, the pathway architecture is not conserved in other species of bacteria. Interestingly, ''B. subtilis'' behaves in an identical manner to ''E. coli'' with regards to chemotaxis. The pathways in the two bacteria also have homologous proteins. Yet, how these proteins are “wired” to one another in the two pathways is entirely different. We seek to understand why these two pathways are “wired” differently and the extent of degeneracy in the basic design. | ||
'''Attractant binding induces distinct structural changes to the polar and lateral signaling clusters in ''Bacillus subtilis'' chemotaxis.''' <br> | '''Attractant binding induces distinct structural changes to the polar and lateral signaling clusters in ''Bacillus subtilis'' chemotaxis.''' <br> | ||
''Journal of Biological Chemistry'', November 2010, <br> | ''Journal of Biological Chemistry'', November 2010, <br> | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/21098025 PubMed] | [http://www.ncbi.nlm.nih.gov/pubmed/21098025 PubMed] | ||
'''Site-specific methylation in ''Bacillus subtilis'' chemotaxis: The effect of covalent modifications to the chemotaxis receptor McpB.''' <br> | '''Site-specific methylation in ''Bacillus subtilis'' chemotaxis: The effect of covalent modifications to the chemotaxis receptor McpB.''' <br> | ||
''Microbiology'', September 2010, <br> | ''Microbiology'', September 2010, <br> | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/20864474 PubMed] | [http://www.ncbi.nlm.nih.gov/pubmed/20864474 PubMed] | ||
'''A PAS domain binds asparagine in the chemotaxis receptor McpB in ''Bacillus subtilis''''' <br> | '''A PAS domain binds asparagine in the chemotaxis receptor McpB in ''Bacillus subtilis''''' <br> | ||
''Journal of Biological Chemistry'', 285(3):1870-8, 2010 <br> | ''Journal of Biological Chemistry'', 285(3):1870-8, 2010 <br> | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/19864420 PubMed] [http://toothbase.scs.uiuc.edu/~chris/glekas_jbc2010.pdf PDF] | [http://www.ncbi.nlm.nih.gov/pubmed/19864420 PubMed] [http://toothbase.scs.uiuc.edu/~chris/glekas_jbc2010.pdf PDF] | ||
'''The molecular basis of excitation and adaptation during chemotactic sensory transduction in bacteria''' <br> | '''The molecular basis of excitation and adaptation during chemotactic sensory transduction in bacteria''' <br> | ||
''Contributions to Microbiology'', 16:33-64, 2009 <br> | ''Contributions to Microbiology'', 16:33-64, 2009 <br> | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/19494578 PubMed] [http://toothbase.scs.uiuc.edu/~chris/raoordal2009.pdf PDF] | [http://www.ncbi.nlm.nih.gov/pubmed/19494578 PubMed] [http://toothbase.scs.uiuc.edu/~chris/raoordal2009.pdf PDF] | ||
'''The three adaptation systems of ''Bacillus subtilis chemotaxis''''' <br> | '''The three adaptation systems of ''Bacillus subtilis chemotaxis''''' <br> | ||
''Trends in Microbiology'', 16(10):480-7, 2008 <br> | ''Trends in Microbiology'', 16(10):480-7, 2008 <br> | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/18774298 PubMed] [http://toothbase.scs.uiuc.edu/~chris/rao_trends2008.pdf PDF] | [http://www.ncbi.nlm.nih.gov/pubmed/18774298 PubMed] [http://toothbase.scs.uiuc.edu/~chris/rao_trends2008.pdf PDF] | ||
'''Phosphatase localization in bacterial chemotaxis: divergent mechanisms, convergent principles''' <br> | '''Phosphatase localization in bacterial chemotaxis: divergent mechanisms, convergent principles''' <br> | ||
''Physical Biology'', 14;2(3):148-58, 2005 <br> | ''Physical Biology'', 14;2(3):148-58, 2005 <br> | ||
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[http://www.ncbi.nlm.nih.gov/pubmed/16224120 PubMed] [http://toothbase.scs.uiuc.edu/~chris/rao2005.pdf PDF] | [http://www.ncbi.nlm.nih.gov/pubmed/16224120 PubMed] [http://toothbase.scs.uiuc.edu/~chris/rao2005.pdf PDF] | ||
'''Design and diversity in bacterial chemotaxis: a comparative study in ''Escherichia coli'' and ''Bacillus subtilis''''' <br> | '''Design and diversity in bacterial chemotaxis: a comparative study in ''Escherichia coli'' and ''Bacillus subtilis''''' <br> | ||
''PLoS Biology'', 2(2):E49, 2004 <br> | ''PLoS Biology'', 2(2):E49, 2004 <br> | ||
[[User:ChrisRao|Rao CV]], Kirby JR, Arkin AP <br> | [[User:ChrisRao|Rao CV]], Kirby JR, Arkin AP <br> | ||
[http://www.ncbi.nlm.nih.gov/pubmed/14966542 PubMed] [http://toothbase.scs.uiuc.edu/~chris/rao_plos2004.pdf PDF] | [http://www.ncbi.nlm.nih.gov/pubmed/14966542 PubMed] [http://toothbase.scs.uiuc.edu/~chris/rao_plos2004.pdf PDF] |
Revision as of 18:32, 16 December 2010
Rao Lab
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