Rao:Projects

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This page is still under construction.
This page is still under construction.

Revision as of 21:22, 16 December 2010

Rao Lab

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This page is still under construction.


Bacillus subtilis Chemotaxis

We are investigating chemotaxis in the model Gram-positive bacterium Bacillus subtilis. While Escherichia coli has long been the paradigm for bacterial chemotaxis, the pathway architecture is not conserved in other species of bacteria. Interestingly, B. subtilis behaves in an identical manner to E. coli with regards to chemotaxis. The pathways in the two bacteria also have homologous proteins. Yet, how these proteins are “wired” to one another in the two pathways is entirely different. We seek to understand why these two pathways are “wired” differently and the extent of degeneracy in the basic design.


Attractant binding induces distinct structural changes to the polar and lateral signaling clusters in Bacillus subtilis chemotaxis.
Journal of Biological Chemistry, November 2010,
Wu K, Walukiewicz HE, Glekas GD, Ordal GW, Rao CV
PubMed


Site-specific methylation in Bacillus subtilis chemotaxis: The effect of covalent modifications to the chemotaxis receptor McpB.
Microbiology, September 2010,
Glekas GD, Cates JR, Cohen TM, Rao CV, Ordal GW
PubMed


A PAS domain binds asparagine in the chemotaxis receptor McpB in Bacillus subtilis
Journal of Biological Chemistry, 285(3):1870-8, 2010
Glekas GD, Foster RM, Cates JR, Estrella JA, Wawrzyniak MJ, Rao CV, Ordal GW
PubMed PDF


The molecular basis of excitation and adaptation during chemotactic sensory transduction in bacteria
Contributions to Microbiology, 16:33-64, 2009
Rao CV, Ordal GW
PubMed PDF


The three adaptation systems of Bacillus subtilis chemotaxis
Trends in Microbiology, 16(10):480-7, 2008
Rao CV, Glekas GD, Ordal GW
PubMed PDF


Phosphatase localization in bacterial chemotaxis: divergent mechanisms, convergent principles
Physical Biology, 14;2(3):148-58, 2005
Rao CV, Kirby JR, Arkin AP
PubMed PDF


Design and diversity in bacterial chemotaxis: a comparative study in Escherichia coli and Bacillus subtilis
PLoS Biology, 2(2):E49, 2004
Rao CV, Kirby JR, Arkin AP
PubMed PDF

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