Renhao Li Lab:Publications

Home        Research        Publications        Protocols        Lab Members        Gallery       

2013

32. P. Mou, Z. Zeng, Q. Li, X. Liu, X. Xin, K. M. Wannemacher, C. Ruan, R. Li, L. F. Brass, L. Zhu.

Identification of a calmodulin-binding domain in Sema4D that regulates its exodomain shedding in platelets.

Blood in press

31. R. Li, J. Emsley.

The organizing principle of platelet glycoprotein Ib-IX-V complex.

J. Thromb. Haemost. in press Pubmed

2012

30. X. Mo, L. Liu, J. A. Lopez, R. Li.

Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex.

J. Thromb. Haemost. 10: 1875-1886, 2012. Pubmed

Made journal cover Gallery

2011

29. R. Yan, X. Mo, A. M. Paredes, K. Dai, F. Lanza, M. A. Cruz, R. Li.

Reconstitution of platelet glycoprotein Ib-IX complex in phospholipid bilayer nanodiscs.

Biochemistry 50: 10598-10606, 2011. Pubmed

28. P. A. McEwan, W. Yang, K. H. Carr, X. Mo, X. Zheng, R. Li*, J. Emsley*. (*, co-corresponding author)

Quaternary organization of GPIb-IX complex and insights into Bernard-Soulier syndrome revealed by the structures of GPIbβ and a GPIbβ/GPIX chimera.

Blood 118: 5292-5301, 2011. Pubmed or Blood online

with commentary in Blood 118: 5065-5066 Blood online

27. W. Deng, S. Srinivasan, X. Zheng, J. A. Putkey, R. Li.

Interaction of calmodulin with L-selectin at the membrane interface: implication on the regulation of L-selectin shedding.

J. Mol. Biol. 411: 220-233, 2011. Pubmed

26. S. Srinivasan, W. Deng, R. Li.

L-selectin transmembrane and cytoplasmic domains are monomeric in membranes.

Biochim. Biophys. Acta 1808: 1709-1715, 2011. Pubmed

25. Z. Zhou, H.-C. Yeh, H. Jing, C. Wang, Z. Tao, H. Choi, K. Aboulfatova, R. Li, J.-F. Dong.

Cysteine residues in CUB-1 domain are critical for ADAMTS13 secretion and stability.

Thromb. Haemost. 105: 21-30, 2011. Pubmed

2010

24. X. Mo, N. X. Nguyen, F.-T. Mu, W. Yang, S.-Z. Luo, H. Fan, R. K. Andrews, M. C. Berndt, R. Li.

Trans-membrane and trans-subunit regulation of ectodomain shedding of platelet glycoprotein Ibα.

J. Biol. Chem. 285: 32096-32104, 2010. Pubmed

23. R. Li.

A hypothesis that explains the heterogeneity of drug-induced immune thrombocytopenia.

Blood 115: 914, 2010. Pubmed

2009

22. X. Mo, N. X. Nguyen, P. A. McEwan, X. Zheng, J. A. López, J. Emsley, R. Li.

Binding of platelet glycoprotein Ibβ through the convex surface of leucine-rich repeats domain of glycoprotein IX.

J. Thromb. Haemost. 7: 1533-1540, 2009. Pubmed

21. Z. Zhou, H. Jing, Z. Tao, H. Choi, K. Aboulfatova, J. Moake, R. Li, J.-F. Dong.

Effects of naturally occurring mutations in CUB-1 domain on synthesis, stability, and activity of ADAMTS-13.

Thromb. Res. 124: 323-327, 2009. Pubmed

2008

20. X. Mo, S.-Z. Luo, J. A. López, R. Li.

Juxtamembrane basic residues in the glycoprotein Ibβ cytoplasmic domain are required for assembly and surface expression of glycoprotein Ib-IX complex.

FEBS Lett. 582: 3270-3274, 2008. Pubmed

19. S.-Z. Luo, R. Li.

Specific heteromeric association of four transmembrane peptides derived from platelet glycoprotein Ib-IX complex.

J. Mol. Biol. 382: 448-457, 2008. Pubmed

18. X. Mo, S.-Z. Luo, A. D. Munday, W. Sun, M. C. Berndt, J. A. López, J.-F. Dong, R. Li.

The membrane-proximal intermolecular disulfide bonds in glycoprotein Ib influence receptor binding to von Willebrand factor.

J. Thromb. Haemost. 6: 1789-1795, 2008. Pubmed

2007

17. S.-Z. Luo, X. Mo, J. A. López, R. Li.

Role of the transmembrane domain of glycoprotein IX in assembly of the glycoprotein Ib-IX complex.

J. Thromb. Haemost. 5: 2494-2502, 2007. Pubmed

16. S.-Z. Luo, X. Mo, V. Afshar-Kharghan, S. Srinivasan, J. A. López, R. Li.

Glycoprotein Ibα forms disulfide bonds with 2 glycoprotein Ibβ subunits in the resting platelet.

Blood 109: 603-609, 2007. Pubmed

(with commentary in Blood 109: 393-394)

2006

15. X. Mo, N. Lu, A. Padilla, J. A. López, R. Li.

The transmembrane domain of glycoprotein Ibβ is critical to efficient surface expression of glycoprotein Ib-IX complex in the plasma membrane.

J. Biol. Chem. 281: 23050-23059, 2006. Pubmed

2005

14. Y. Peng, Z. Tao, L. Nolasco, S. Cal, C. Lopez-Otin, R. Li, J. F. Moake, J. A. López, J.-F. Dong

Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions.

Blood 106: 4139-4145, 2005. Pubmed

Postdoctoral Work

13. W. Li, D. G. Metcalf, R. Gorelik, R. Li, N. Mitra, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

A push-pull mechanism for regulating integrin function.

Proc. Natl. Acad. Sci. 102: 1424-1429, 2005.

12. R. Li, R. Gorelik, V. Nanda, P. B. Law, J. D. Lear, W. F. DeGrado, J. S. Bennett

Dimerization of the transmembrane domain of integrin αIIb subunit in cell membranes.

J. Biol. Chem. 279: 26666-26673, 2004.

11. R. Li, J. S. Bennett, W. F. DeGrado

Structural basis for integrin αIIbβ3 clustering.

Biochem. Soc. Trans. 32: 412-415, 2004.

10. R. Li, N. Mitra, H. Gratkowski, G. Vilaire, R. Litvinov, C. Nagasami, J. W. Weisel, J. D. Lear, W. F. DeGrado, J. S. Bennett

Activation of integrin αIIbβ3 by modulation of transmembrane helix associations.

Science 300: 795-798, 2003.

(commentary in Science 300: 755-756)

9. R. Li, R. H. Hoess, J. S. Bennett, W. F. DeGrado

Use of a phage displayed protein scaffold for determining binding specificity to integrins.

Protein Eng. 16: 65-72, 2003.

8. R. Li, C. R. Babu, K. Valentine, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of integrin β3 subunit by NMR spectroscopy.

Biochemistry 41: 15618-15624, 2002.

5. R. Li, C. R. Babu, J. D. Lear, A. J. Wand, J. S. Bennett, W. F. DeGrado

Oligomerization of the integrin αIIbβ3: roles of the transmembrane and cytoplasmic domains.

Proc. Natl. Acad. Sci. 98: 12462-12467, 2001.

Graduate Work

7. R. Li, J. L. Battiste, C. Woodward

Native-like interactions favored in the unfolded bovine pancreatic trypsin inhibitor have different roles in folding.

Biochemistry 41: 2246-2253, 2002.

6. J. L. Battiste, R. Li, C. Woodward

A highly destabilizing mutation, G37A, of the bovine pancreatic trypsin inhibitor retains the average native conformation but greatly increases local flexibility.

Biochemistry 41: 2237-2245, 2002.

4. K. Akasaka, H. Li, H. Yamada, R. Li, T. Thoresen, C. Woodward

Pressure response of protein backbone structure. Pressure-induced amide 15N-chemical shifts in BPTI.

Protein Sci. 8: 1946-1953, 1999.

3. R. Li, C. Woodward

The hydrogen exchange core and protein folding.

Protein Sci. 8: 1571-1590, 1999.

2. C. Woodward, R. Li

The slow-exchange core and protein folding.

Trends Biochem. Sci. 23: 379-381, 1998.

1. J. Ng, R. Li, K. Morgan, J. Simon.

Evolutionary conservation and predicted structure of the Drosophila extra sex combs repressor protein.

Mol. Cell. Biol. 17: 6663-6672, 1997.