Ritty Lab:Home
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We are primarily interested in connective tissue tumors.Specifically, we are investigating two metastatic mechanisms of osteosarcoma. First, we hypothesize that specific integrins mediate metastatic invasion of tissues, and that loss or overexpression of an integrin receptor therefore alters metastatic potential. Second, osteosarcoma cells alter their expression of matrix metalloproteinases after attachment to extracellular matrix proteins. We hypothesize this feedback loop mechanism influences osteosarcoma metastatic ability. We employ a variety of cellular and molecular methods to investigate our hypotheses. Click here for more details: [[Ritty Lab:research]] | We are primarily interested in connective tissue tumors.Specifically, we are investigating two metastatic mechanisms of osteosarcoma. First, we hypothesize that specific integrins mediate metastatic invasion of tissues, and that loss or overexpression of an integrin receptor therefore alters metastatic potential. Second, osteosarcoma cells alter their expression of matrix metalloproteinases after attachment to extracellular matrix proteins. We hypothesize this feedback loop mechanism influences osteosarcoma metastatic ability. We employ a variety of cellular and molecular methods to investigate our hypotheses. Click here for more details: [[Ritty Lab:research]] | ||
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Revision as of 10:49, 17 September 2009
Welcome to the Ritty Lab Homepage
We are located at the Penn State University College of Medicine. Click here for more details: Ritty Lab:contact
We are primarily interested in connective tissue tumors.Specifically, we are investigating two metastatic mechanisms of osteosarcoma. First, we hypothesize that specific integrins mediate metastatic invasion of tissues, and that loss or overexpression of an integrin receptor therefore alters metastatic potential. Second, osteosarcoma cells alter their expression of matrix metalloproteinases after attachment to extracellular matrix proteins. We hypothesize this feedback loop mechanism influences osteosarcoma metastatic ability. We employ a variety of cellular and molecular methods to investigate our hypotheses. Click here for more details: Ritty Lab:research
