Robert W Arnold Week 4: Difference between revisions

Revision as of 16:15, 21 September 2011

Finished up Journal Club, had a good talk with the class about the research article. Really brought to light some questions I had when going through the research, specifically about CD4 T cells and how they work.
Started to come up with ideas for presentation, mainly thinking about researching the 6 of the 15 subjects which developed AIDS. I want to determine which ones specifically developed AIDS, their CD4 T call counts, dS/dN ratio, what they have in common with each other and what they don't have in common with the other subjects.

Which 6 of the 15 subjects developed AIDS? Why did these 6 develop AIDS? What do they have in common with each other? Specifically, CD4 T cell count, rapid, moderate or nonprogressor, dS/dN ratio, etc. What do they not have in common with the subjects who did not develop AIDS?
We believe that the dS/dN ratios of the 6 subjects is the most telling factor in what determines if those subjects develop AIDS. We hope to prove that extremely low dS/dN ratios of 0.0, 0.2, and 0.3 will prove to be a determining factor in developing AIDS. Subjects 4, 9, 11, and 14 all have ratios of 0.0, subject 10 has a ratio on 0.2 and subject 1 has a ratio of 0.3. We do not believe the separation between rapid and moderate progressors has anything to do with AIDS development as subjects 1, 4, 10, and 11 are rapid and subjects 9 and 14 are moderate.
All of the subjects will be viewed to determine which ones developed AIDS. From there we will determine their common factors and why each may have developed AIDS. Then we will compare them to the other subjects and determine if any other subject may be trending towards AIDS.

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 #We believe that the dS/dN ratios of the 6 subjects is the most telling factor in what determines if those subjects develop AIDS.  We hope to prove that extremely low dS/dN ratios of 0.0, 0.2, and 0.3 will prove to be a determining factor in developing AIDS.  Subjects 4, 9, 11, and 14 all have ratios of 0.0, subject 10 has a ratio on 0.2 and subject 1 has a ratio of 0.3.  We do not believe the separation between rapid and moderate progressors has anything to do with AIDS development as subjects 1, 4, 10, and 11 are rapid and subjects 9 and 14 are moderate.
 #All of the subjects will be viewed to determine which ones developed AIDS.  From there we will determine their common factors and why each may have developed AIDS.  Then we will compare them to the other subjects and determine if any other subject may be trending towards AIDS.
+===Basic Initial Research===
+*HIV progresses to AIDS at CD4 T cell counts lower than 200 cells/mm^3. [[http://www.nlm.nih.gov/medlineplus/ency/article/000594.htm]]
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 ==Links==