Robert Werdehausen

Contact information

Dr. Robert Werdehausen (M.D.) - Resident in Anesthesiology

• Departmental address:
  

Department of Anesthesiology, University Hospital Düsseldorf
Building 12.42, Moorenstr. 5, 40225 Düsseldorf, Germany

• Laboratory address (preferred mail address):
  

Experimental Anesthesiology Laboratory, Heinrich-Heine-University of Düsseldorf
Building 23.02.01.R64, Universitätsstr. 1, 40225 Düsseldorf, Germany
Email: robert.werdehausen@uni-duesseldorf.de
Phone: +49 211 81-13991
Fax: +49 211 81-13954

• Current position (Post-doctorate research scientist):
  

Molecular Nociception Group (Head: Professor John N. Wood), Part of the London Pain Consortium (LPC)
Institute for Biomedical Research (WIBR), University College London (UCL)
Cruciform Building, Gower Street, London WC1E 6BT, United Kingdom
Email: r.werdehausen@wibr.ucl.ac.uk
Phone: +44 20 7679 0793

Research interests

• Molecular mechanisms of pain perception
  

• Effects of local and general anesthetics on chronic pain
  

• Neurotoxicity of local and general anesthetics on chronic pain
  

• New techniques in regional anesthesia and pain medicine
  

Selected publications

• Expression of spinal cord microRNAs in a rat model of chronic neuropathic pain.
  Neuroscience Letters 2012 Jan 11;506(2):281-6. PMID: 22138088 Pubmed abstract

• Lidocaine metabolites inhibit glycine transporter 1: a novel mechanism for the analgesic action of systemic lidocaine?
  Anesthesiology. 2012 Jan;116(1):147-58. PMID: 22133759 Pubmed abstract

• Lipophilicity but not stereospecificity is a major determinant of local anaesthetic-induced cytotoxicity in human T-lymphoma cells.
  European Journal of Anaesthesiology 2012 Jan;29(1):35-41. PMID: 22012177 Pubmed abstract

• The influence of adjuvants used in regional anesthesia on lidocaine-induced neurotoxicity in vitro.
  Regional Anesthesia and Pain Medicine 2011 Sep-Oct;36(5):436-43. PMID: 21857277 Pubmed abstract

• The paravertebral lamina technique: a new regional anesthesia approach for breast surgery.
  Journal of Clinical Anesthesia 2011 Sep;23(6):443-50. PMID: 21752620 Pubmed abstract

• Midazolam activates the intrinsic pathway of apoptosis independent of benzodiazepine and death receptor signaling.
  Regional Anesthesia and Pain Medicine 2011 Jul-Aug;36(4):343-9. PMID: 21701267 Pubmed abstract

• Effect of continuous posttraumatic intrathecal nocistatin on the development of mechanical allodynia.
  Regional Anesthesia and Pain Medicine 2011 Jan-Feb;36(1):32-5. PMID: 21455086 Pubmed abstract

• Benzethonium increases the cytotoxicity of S(+)-ketamine in lymphoma, neuronal, and glial cells.
  Anesthesia & Analgesia 2010 Dec;111(6):1389-93. PMID: 20889936 Pubmed abstract

• Ketamine induces apoptosis via the mitochondrial pathway in human lymphocytes and neuronal cells.
  British Journal of Anaesthesia 2010 Sep;105(3):347-54. PMID: 20659914 Pubmed abstract

• Apoptosis induction by different local anaesthetics in a neuroblastoma cell line.
  British Journal of Anaesthesia 2009 Nov;103(5):711-8. PMID: 19700777 Pubmed abstract

• Loss of spinal glycinergic neurons is not necessary for development of neuropathic pain in transgenic mice expressing enhanced green fluorescent protein in glycinergic neurons.
  Neuroscience. 2009 Mar 31;159(3):1148-53. PMID: 19356695 Pubmed abstract

• Lidocaine protects from myocardial damage due to ischemia and reperfusion in mice by its antiapoptotic effects.
  Anesthesiology. 2009 May;110(5):1041-9. PMID: 19352171 Pubmed abstract

• Differential effects of spinally applied glycine transporter inhibitors on nociception in a rat model of neuropathic pain.
  Neuroscience Letters 2008 Nov 21;445(3):214-9. PMID: 18793697 Pubmed abstract

• Skin temperature after interscalene brachial plexus blockade.
  Regional Anesthesia and Pain Medicine 2007 Nov-Dec;32(6):481-7. PMID: 18035293 Pubmed abstract

• Stimulating catheter as a tool to evaluate peripheral nerve function during hip rotationplasty.
  Regional Anesthesia and Pain Medicine 2007 Nov-Dec;32(6):528-32. PMID: 18035301 Pubmed abstract

• Lidocain induces apoptosis via the mitochondrial pathway independently of death receptor signaling.
  Anesthesiology. 2007 Jul;107(1):136-143. PMID: 17585225 Pubmed abstract

• Does interscalene catheter placement with stimulating catheters improve postoperative pain or functional outcome after shoulder surgery?
  A prospective, randomized and double-blinded trial.
  Anesthesia & Analgesia 2007 Feb;104(2):442-7. PMID: 17242107 Pubmed abstract

• Uniform distribution of skin-temperature increase after different regional-anesthesia techniques of the lower extremity.
  Regional Anesthesia and Pain Medicine 2007 Jan-Feb;32(1):73-8. PMID: 17196496 Pubmed abstract, PDF

• Sedation during spinal anaesthesia in infants.
  British Journal of Anaesthesia 2006 Sep;97(3):380-4. PMID: 16816395 Pubmed abstract

• Skin temperature during regional anesthesia of the lower extremity.
  Anesthesia & Analgesia 2006 Apr;102(4):1247-51. PMID: 16551932 Pubmed abstract, full text / letters

Memberships

• International Anesthesia Research Society (IARS)
• German Society for Anesthesiology and Intensive Care Medicine (DGAI)
• Subcommittee on Young Scientists (WAKWiN, DGAI)
• Selected mentee of the Mentoring Program for Junior Investigators (DGAI)

Grants and awards

• 2nd price at the scientific presentation competition (German Anesthesiology Congress 2006)
• 3rd price at the scientific poster presentation (European Society of Regional Anaesthesia (ESRA) congress 2007)
• Research Fellowship of the German Research Foundation (DFG) 2011-2013
• DGAI Research Fellowship 2012 funded by the Fresenius Trust