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| ==Introduction== | | ==Introduction== |
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| We intend to use this space to seed, prioritize and sustain a list of 'Top 10 gaps' in our practice of synthetic biology for this group - and others - to consider, discuss, and work towards addressing. We ideally hope to produce from the discussions documented and materials collected here a series of simple, digestible co-authored papers summarizing each gap, current practices, open questions, and recommendations for moving forward. | | We intend to use this space to seed, prioritize and sustain a list of 'Top gaps' in the practice of synthetic biology for this group - and others - to consider, discuss, and work towards addressing. We ideally hope to produce from the discussions documented and materials collected here a simple, digestible co-authored paper, or papers, summarizing each gap, current practices, open questions, and recommendations for moving forward. |
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| ==Gap Seed List== | | ==Current Gap List== |
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| ===About the Gap Seed List and Editing Methodology===
| | [[SBPWG:Gaps/Gaps_Draft_v4 | Gaps List v4 SynBERC Fall Retreat]]: Gaps Presented and Gathered at the SynBERC Fall Retreat |
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| The gaps below were first outlined by participants of the June 30th 2011 Working Group Meeting. This is a rough draft and should be considered a living document to be revised (or re-conceived!) as the contributors see fit. Edit ruthlessly, add comments, references, examples, questions - anything that will be helpful. Don't worry about messing anything up - the wiki allows us to revert to old versions!
| | ==Previous Gap List Drafts and References== |
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| At least one person should indicate they will take the lead for '''synthesizing comments into a clear, digestible paragraph outlining the gap, current practices and open questions''' (though everyone should feel free to add content!). Please '''indicate your chosen gap(s) to take the lead on by placing your name beside 'content lead'''' - first come first served. If you have additional gaps, or want to combine gaps, please add them to the list bottom of the list as a newly enumerated gap, and also indicate if it represents a split or merge of other gap(s). This is a work in progress, so give it a good shot, but expect the final product to change!
| | [[SBPWG:Gaps/Gaps_Draft_v3 | Gap Seed List v3 - July 27th for Working Group Meeting ]]: Gap seed list used for discussion at the July 27th Working Group Meeting - combines elements of several drafts from below. Please edit! |
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| '''Please have a first draft of your paragraphs before our next meeting on July 18th!'''
| | [[SBPWG:Gaps/Gaps_Draft_v2 | Gap Seed List v2 - July 22nd for SAB Call ]]: Gap seed list drafted for feedback from the SynBERC SAB |
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| | [https://spreadsheets.google.com/spreadsheet/viewform?formkey=dGp3ZXp5MHhrRW84YUNHRVN4b0tYeUE6MQ Wilson ELSI Issues Survey] Link to the Wilson Center's list of critical ELSI issues related to Synthetic Biology. They are expanding this list via an on-line survey, and after gathering additional ideas will be posting an online poll to allow people to prioritize the most important issues. |
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| (The list is not yet prioritized, but I have rearranged the list into three main groups, retaining the original numbering to preserve cross-listing. - JV)
| | [[SBPWG:Gaps/Gaps_Draft_v1 | Gap Seed List v1 - June 30th 2011 ]]: Gap seed list first outlined by participants of the June 30th 2011 Working Group Meeting: |
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| | | [http://celect.lids.mit.edu/ Select] is a potential tool for prioritizing gaps |
| ===A) How Information is Produced, Shared, Disseminated, Coordinated, and Protected===
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| While new scientific knowledge is generated from a variety of sources (DIY, research institutions and private corporations from around the world), all synthetic biologists benefit from access to the work of their peers. Furthermore, coordination among scientists minimizes redundant research, freeing up time and resources for the pursuit of new areas or the further development of existing areas. However, ownership of one's own work and the ability to profit from that work are important incentives that must be maintained if scientists and their supporters are to continue investing effort and money into new research. The conflict between these opposing ideals must be resolved for the full potential of synthetic biology to be realized. - JV
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| ====0. Relationship between DIY and Synthetic Biology Communities====
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| * Content Lead:
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| * Should there be similar expectations of responsible conduct between institutional and non-institutional actors?
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| * How are we held mutually accountable for each others' actions?
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| ====1. Ownership, Sharing and Innovation - Property Rights Frameworks for Synthetic Biology====
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| * Content Lead:
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| * At what level in the abstraction hierarchy of envisioned biological designs should we instill property rights?
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| * How does IP determine relationships, scaling, dissemination, commercialization of technology?
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| * How do scientists deal with the fact we're not lawyers? How do we know if and how we should publish and or/share our parts/devices/organisms?
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| ====2. Collaboration, Sharing of Parts and the Security / IP implications thereof====
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| * Content Lead:
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| * exposure vs scooping
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| * possibilities for interception of work by national security as in other fields?
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| * parts registries - whether or not to release consent
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| * unknown trajectory to privacy
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| * institutionalization and access (e.g. cocaine available through Sigma to academic labs, not public)
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| * e.g. of needing confidentiality, ownership agreements w/ labs before they will share their parts (Joe S)
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| ====9. International Collaboration and Competition====
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| * Content Lead:
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| * How do we coordinate between countries re: regulation, safety, security?
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| * How to balance competition, collaboration - where and how should we invest?
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| * The internet changes everything
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| ===B) Public Communication between the Scientific Community and Other Sectors of Society===
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| The scientific community does not exist in isolation, but rather is one aspect of human society populated by myriad groups with their own (concurrent, orthogonal, or opposing) agendas. Society as a whole determines what research may be performed (through laws and funding) and how the products of that research are used. Strong communication between scientists and the rest of society is important to ensure the perception and reality that scientific progress benefits society as a whole. - JV
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| ====3. Low National Scientific Literacy as an impediment to Constructive Dialogue around Emerging Technologies====
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| * Content Lead:
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| * decelerating pace of scientific literacy in the US vs other countries
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| * public perceptions frame tech developments
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| * what are the best channels of scientific information that reach publics (e.g. blogs, realclimate.org, reddit, quora, Factcheck.org)
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| * even within community we have a diverse community of new practitioners
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| * Establishing Meaningful Dialogues with Diverse Stakeholders - How can deliver reliable information about synthetic biology to the publics?
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| * How can we anticipate and respond proactively to public/societal sentiments on biotechnology?
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| * e.g. ETC group letter to SB5 concerned that civil society wasn't included
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| ====4. Responding to Other Philosophies and Agendas====
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| * Content Lead:
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| * Perhaps Related to (the same as?) 3, but dealing with explicitly antagonistic agendas (e.g. PETA?)
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| * How to recognize, respect dissenting views, philosophies, moral frameworks, philosophies - should these impact decision making?
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| * Are there limits to rational, constructive dialog?
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| ====6. Defining 'Poster Children' for Synthetic Biology====
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| * Content Lead:
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| * We are much better at articulating risks and telling of stories of failures than the past or future successes. This frames our conversation with the public, govt, regulators etc.
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| * So focused on not being Monsanto, GMOs that our conversations revolve around risk instead of benefits.
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| * Possibly could details success stories: Insulin, Amyris, Selective Breeding, Antifreeze Tomatoes etc
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| * How do we relate how SB could touch and improve people's lives?
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| ====7. Practical Frameworks for Responding to Political Forces/Situtation that Frame Our Work====
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| * Content Lead:
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| * Land Use Politics
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| * Existing Systems of Belief
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| ====8. Biotechnology Innovation Roadmap====
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| * Content Lead:
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| * Do we have a roadmap outlining near-term and long-term deliverables of synthetic biology, their context wrt other (bio)technologies and where they offer either new application areas and/or more cost effective solutions?
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| * This would help us and other
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| * What are the key decision points, areas for investment to accelerate innovation
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| * Economic Forecasting for Synthetic Biology Technology Developments
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| ====10. Education, Training and Identity Across a Diverse Community of Practitioners====
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| * Content Lead: Megan
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| * How savy should we expect researchers to be wrt the broader context of technology developments?
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| * How do we engage and inspire leadership on practices in a way that aligns with our technical goals, interests?
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| * How do deal with generational transfer of knowledge and immigration from a broad array of disciplines?
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| ====13. Developing Trust in a World of Profits and Secrets ====
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| * Content Lead:
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| * Relation to 2, 5
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| * How can we be ambassadors for biosafety when we do not have knowledge of research ongoing at private companies and in secure govt labs?
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| ===C) Potential Negative Consequences===
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| Synthetic biology has potential to do great good for the world, but it also has the potential for great harm. There exists the danger for the products of synthetic biology to be abused, misused, or unjustly distributed. Care must also be taken to prevent synthetic organisms from escaping human control and damaging human life or the environment. The risks of these negative consequences must be weighed against the potentially generated benefits when determining what research to restrict or entirely disallow. Alternatively, certain potentially dangerous research may be allowed to proceed, with regulation occurring only downstream at product implementation. - JV
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| ====5. Risk Analysis Frameworks for Emerging Technologies====
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| * Content Lead:
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| * How do we deal with the unknown unknowns? Are we dealing with the known unknowns?
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| * How can we claim, justify safety of things we haven't yet built?
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| * How do we frame both risk and opportunity?
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| * How do we do ecosystem clinical trials?
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| * If we say it's safe, why should you trust us?
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| * What are appropriate risk assessment frameworks for intentional & unintentional environmental release?
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| * How do we approach regulation of cross-cutting technology platforms spanning multiple disjointed regulatory bodies set primarily by application area?
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| * Can we develop experimental systems for assessing safety?
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| * e.g. rE.Coli - ' safer chassis, but no regulatory framework so hard to commercialize
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| * e.g. http://trib.com/news/state-and-regional/article_6945effb-0af4-53ab-ba93-af79461f1535.html
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| * Risk Governance & SB report http://www.irgc.org/IMG/pdf/irgc_SB_final_07jan_web.pdf
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| ====11. Preparedness for Syn Bio (-Labeled) Accidents ====
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| * Content Lead:
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| * Mistakes will happen. Accidents will happen. Somebody can be expected to misused this technology - Do we have a community response plan? Who will be held accountable?
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| * http://www.nature.com/nbt/journal/v27/n12/full/nbt1209-1109.html
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| ====12. Technology Distribution and Accessibility - Justice ====
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| * Content Lead:
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| * How do we develop the technology so that it doesn't serve/benefit only the privileged, elite?
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| ===Prioritization - My Gaps and Your Gaps===
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| Participants at the Working Group Meeting were asked to list their top 2 gaps that 'somebody' should be resolving, and which amongst those they felt were their responsibility
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| '''Gaps Someone Should Mind'''
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| *0.
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| *1. JS, JV, DTE, AK
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| *2.
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| *3. RR, JS, JV, DTE, MF, AK
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| *4.
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| *5.RR. SA
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| *6.
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| *7.
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| *8.MP
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| *9.
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| *10. MF, MP
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| *11.
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| *12. JV, SA
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| *13.
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| '''Gaps I Should Mind'''
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| *0.
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| *1. DTE
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| *2. JS ( already affected, part collab), RR, DTE
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| *3. JS (educator), RR, JV++, DTE, AK
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| *4.
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| *5. RR, SA
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| *6. DTE
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| *7.
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| *8. MP
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| *9.
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| *10. MP
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| *11.
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| *12.
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| *13.
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