Saeij lab: Difference between revisions

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==Overview==
==Overview==
 
The primary research interest of our laboratory is to understand how intracellular parasites exploit and manipulate the host cells in which they live to ensure their survival, replication and transmission and hence their success. Our experimental model is ''Toxoplasma gondii'', considered the most successful protozoan parasite of warm-blooded animals. The focus of my laboratory over the last years has been to identify genes of ''Toxoplasma'' that determine virulence, host genes and pathways that determine resistance/susceptibility, and to characterize their specific interactions. To achieve this we use a combination of genomics, biochemistry, genetics, microscopy, immunology and computational tools.  
The primary research interest of our laboratory is to understand how intracellular parasites exploit and manipulate the host cells in which they live, to ensure their survival, replication, and transmission, and hence their success. Our experimental focus is Toxoplasma gondii, considered the most successful protozoan parasite of warm-blooded animals. We are interested in identifying Toxoplasma proteins involved in the modulation of the host cell and the exact mechanisms by which they act. We are also interested in understanding the genetic basis of individual differences in susceptibility to infectious diseases. To achieve this we use a combination of genomics, biochemistry, genetics, microscopy, immunology and computational tools.  





Revision as of 09:31, 26 August 2011

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Overview

The primary research interest of our laboratory is to understand how intracellular parasites exploit and manipulate the host cells in which they live to ensure their survival, replication and transmission and hence their success. Our experimental model is Toxoplasma gondii, considered the most successful protozoan parasite of warm-blooded animals. The focus of my laboratory over the last years has been to identify genes of Toxoplasma that determine virulence, host genes and pathways that determine resistance/susceptibility, and to characterize their specific interactions. To achieve this we use a combination of genomics, biochemistry, genetics, microscopy, immunology and computational tools.


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