The primary research interest of our laboratory is to understand how intracellular parasites exploit and manipulate the host cells in which they live, to ensure their survival, replication, and transmission, and hence their success. Our experimental focus is Toxoplasma gondii, considered the most successful protozoan parasite of warm-blooded animals. We are interested in identifying Toxoplasma proteins involved in the modulation of the host cell and the exact mechanisms by which they act. We are also interested in understanding the genetic basis of individual differences in susceptibility to infectious diseases. To achieve this we use a combination of genomics, biochemistry, genetics, microscopy, immunology and computational tools.