Saeij lab:Reprints: Difference between revisions
Jeroen Saeij (talk | contribs) |
Jeroen Saeij (talk | contribs) |
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==Publications== | ==Publications== | ||
Minot S$, Melo MB$, Li F, Lu D, Niedelman W, Levine SS, '''Saeij JPJ'''. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. [http://www.ncbi.nlm.nih.gov/pubmed/22847430 Proc Natl Acad Sci U S A. 2012 ;109(33):13458-6.] $ These authors contributed equally<br><br> | Minot S$, Melo MB$, Li F, Lu D, Niedelman W, Levine SS, '''Saeij JPJ'''. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. [http://www.ncbi.nlm.nih.gov/pubmed/22847430 Proc Natl Acad Sci U S A. 2012 ;109(33):13458-6.] $ These authors contributed equally<br><br> | ||
''In this manuscript we used a genome-wide SNP set from 26 different strains, representing global diversity, to show that most current isolates are recent recombinants and cannot be easily grouped into a limited number of haplogroups. A complex picture emerges in which some genomic regions have not been recently exchanged between any strains, and others recently spread from one strain to many others. Particularly, three haploblocks, on chrIa, XI, and XII, have recent common ancestry across multiple diverse lineages, perhaps suggesting that these regions may contain fitness loci. Our approach improves upon current methods because it analyzes recombination-defined haploblocks, building a more precise and comprehensive genealogy of Toxoplasma. We also put forward the hypothesis that the limited Toxoplasma diversity in North America might be a result of the late Pleistocene extinction (∼11,500 y ago), which eliminated ∼80% of large vertebrates in North America, including most Felidae members, causing a severe bottleneck and the demise of most North American Toxoplasma strains.''<br><br> | |||
Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, '''Saeij JPJ'''. The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response. [http://www.ncbi.nlm.nih.gov/pubmed/22761577 PLoS Pathog. 2012 Jun;8(6):e1002784.]<br><br> | Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, '''Saeij JPJ'''. The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response. [http://www.ncbi.nlm.nih.gov/pubmed/22761577 PLoS Pathog. 2012 Jun;8(6):e1002784.]<br><br> |
Revision as of 12:21, 1 September 2012
PublicationsMinot S$, Melo MB$, Li F, Lu D, Niedelman W, Levine SS, Saeij JPJ. Admixture and recombination among Toxoplasma gondii lineages explain global genome diversity. Proc Natl Acad Sci U S A. 2012 ;109(33):13458-6. $ These authors contributed equally Niedelman W, Gold DA, Rosowski EE, Sprokholt JK, Lim D, Farid Arenas A, Melo MB, Spooner E, Yaffe MB, Saeij JPJ. The Rhoptry Proteins ROP18 and ROP5 Mediate Toxoplasma gondii Evasion of the Murine, But Not the Human, Interferon-Gamma Response. PLoS Pathog. 2012 Jun;8(6):e1002784. Lim DC, Cooke BM, Doerig C, Saeij JPJ. Toxoplasma and Plasmodium protein kinases: roles in invasion and host cell remodelling.
Int J Parasitol. 2012 Jan;42(1):21-32. Melo MB$, Jensen KDC$, Saeij JPJ. Toxoplasma gondii effectors are master regulators of the inflammatory response. Trends in Parasitology. 2011 Nov;27(11):487-95. $ These authors contributed equally |