|
|
| (17 intermediate revisions by the same user not shown) |
| Line 18: |
Line 18: |
| |style="background:#ffffff"| | | |style="background:#ffffff"| |
| ==Publications== | | ==Publications== |
| 1. Melo MB$, Jensen KDC$, '''Saeij JPJ'''. Toxoplasma gondii effectors are master regulators of the inflammatory response. In Press. Trends in Parasitology. $ These authors contributed equally<br>
| | See our publications at [http://www.saeijlab.com our website] |
| 2. Virreira-Winter S, Niedelman W, Jensen KD, Rosowski RE, Julien L, Spooner E, Caradonna K, Burleigh BA, '''Saeij JPJ''', Ploegh HL, Frickel E. Determinants of GBP recruitment to Toxoplasma gondii vacuoles and the parasitic factors that control it. Accepted. PLoS One.<br>
| |
| 3. Jensen KDC, Wang Y, Wojno ED, Shastri AJ, Hu K, Cornel L, Boedec E, Ong Y, Chien Y, Hunter CA, Boothroyd JC, '''Saeij JPJ'''. Toxoplasma polymorphic effectors determine macrophage polarization and intestinal inflammation. [http://www.ncbi.nlm.nih.gov/pubmed/21669396 Cell Host & Microbe 9(6):472-83; 2011.]<br>
| |
| '''Highlighted in: Macrophages as a battleground for Toxoplasma pathogenesis. ''' [http://www.ncbi.nlm.nih.gov/pubmed/21669391 Cell Host Microbe 9(6):445-7; 2011.]<br>
| |
| MIT news: Biologists shed light on a puzzling parasite [http://web.mit.edu/newsoffice/2011/toxoplasma-crohns-0617.html]<br>
| |
| 4. Reese ML, Zeiner GM, '''Saeij JP''', Boothroyd JC, Boyle JP. Polymorphic family of injected pseudokinases is paramount in Toxoplasma virulence. [http://www.ncbi.nlm.nih.gov/pubmed/21436047 PNAS 108(23):9625-30; 2011.] <br>
| |
| Selected by Faculty of 1000: Factor 6.
| |
| 5. Rosowski E$, Lu D$, Julien L, Rodda L, Gaiser R, Kirk J, '''Saeij JPJ'''. Strain-specific activation of the NF-κB pathway by GRA15, a novel Toxoplasma dense granule protein. [http://www.ncbi.nlm.nih.gov/pubmed/21199955 J Exp Med 208(1):195-212; 2011.] $ These authors contributed equally. <br>
| |
| Selected by Faculty of 1000: Factor 6. <br>
| |
| Highlighted in: It takes II to induce NF-κB. [http://www.ncbi.nlm.nih.gov/pubmed/21451559 Nature Reviews Microbiology 9, 147, 2011. ]<br>
| |
| MIT news: On the trail of a stealthy parasite [http://web.mit.edu/newsoffice/2010/toxoplasmosis-0104.html]<br>
| |
| 6. Blader IJ, '''Saeij JPJ'''. Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. [http://www.ncbi.nlm.nih.gov/pubmed/19400868 APMIS. 117(5-6):458-76; 2009.] <br>
| |
| 7. Boyle JP, '''Saeij JP''', Harada SY, Ajioka JW, Boothroyd JC. Expression quantitative trait locus mapping of toxoplasma genes reveals multiple mechanisms for strain-specific differences in gene expression. [http://www.ncbi.nlm.nih.gov/pubmed/18552283 Eukaryot Cell. 7(8):1403-14; 2008.] <br>
| |
| ''In this paper we used quantitate genetics to identify Toxoplasma genes that are expressed in a strain-specific manner. For one of these genes, the rhoptry kinase ROP18, it is known that it is the difference in expression level between strains that causes differences in virulence. The biological consequences of expression level differences of the other genes is currently unknown.'' <br>
| |
| 8. '''Saeij JPJ''', Arrizabalaga G, Boothroyd JC. A cluster of four surface antigen genes specifically expressed in bradyzoites, SAG2CDXY, plays an important role in Toxoplasma gondii persistence. [http://www.ncbi.nlm.nih.gov/pubmed/18347037 Infection and Immunity 76(6): 2402-2410; 2008. ] <br>
| |
| ''Here we removed for the first time four adjacent genes using double homologous recombination. These are surface antigens that are expressed in bradyzoites but not in tachyzoites. Interestingly, parasites without these surface antigens are less able to persist in the brain of mice. We also show that using a bradyzoite specific promoter driving luciferase expression can show stage conversion in real time in life mice in vivo (using an IVIS imaging system''). <br>
| |
| 9. Boyle JP, '''Saeij JPJ''', Boothroyd Inconsistent dissemination patterns of Toxoplasma gondii following oral infection. [http://www.ncbi.nlm.nih.gov/pubmed/17335814 Experimental Parasitology 116(3):302-305; 2007.] <br>
| |
| 10. '''Saeij JPJ'''$, Coller S$, Boyle JP, Jerome ME, White MW, Boothroyd JC. Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. $ These authors contributed equally. [http://www.ncbi.nlm.nih.gov/pubmed/17183270 Nature 445(7125): 324-327; 2007. ] <br>
| |
| Selected by Faculty of 1000: Factor 17.<br>
| |
| Highlighted in: Toxo researchers spot the difference. [http://www.nature.com/nrmicro/journal/v5/n2/full/nrmicro1607.html Nature Reviews Microbiology 5, 86, 2007. ]<br>
| |
| 11. '''Saeij JPJ'''$, Boyle JP$, Coller SC, Taylor S, Sibley LD, Brooke-Powell ET, Ajioka JW, Boothroyd JC. Polymorphic secreted kinases are key virulence factors in toxoplasmosis. $ These authors contributed equally. [http://www.ncbi.nlm.nih.gov/pubmed/17170306 Science 314(5806):1780-1783; 2006. ] <br>
| |
| Selected by Faculty of 1000: Factor 14.<br>
| |
| Highlighted in: Toxo researchers spot the difference. Nature Reviews Microbiology 5, 86, 2007; Nature Immunology 8, 129 (2007). <br>
| |
| 12. Boyle, JP, Rajasekar B, '''Saeij JPJ''', Ajioka JW, Berriman M, Paulsen I, Roos DS, Sibley D, White M, Boothroyd JC. Just one cross appears capable of dramatically altering the population biology of a eukaryotic pathogen like Toxoplasma gondii. [http://www.ncbi.nlm.nih.gov/pubmed/16801557 PNAS 103(27): 10514-10519; 2006.]<br>
| |
| Selected by Faculty of 1000: Factor 6. <br>
| |
| 13. Boyle JP,''' Saeij JPJ''', Cleary MD, Boothroyd JC. Analysis of gene expression during development: lessons from the apicomplexa. [http://www.ncbi.nlm.nih.gov/pubmed/16697685 Microbes and Infection 8(6): 1623-1630; 2006. ] <br>
| |
| 14. '''Saeij JPJ'''$, Boyle JP$, Grigg ME, Arrizabalaga G, Boothroyd JC. Bioluminescence imaging of Toxoplasma gondii infection in living mice reveals dramatic differences between strains. $ These authors contributed equally. [http://www.ncbi.nlm.nih.gov/pubmed/15664907 Infection and Immunity. 73(2): 695-702; 2005. ] <br>
| |
| Selected by Faculty of 1000: Factor 6. <br>
| |
| 15. Saeij JP'''Bold text'''J, Boyle JP, Boothroyd JC. Differences among the three major strains of Toxoplasma gondii and their specific interactions with the infected host. [http://www.ncbi.nlm.nih.gov/pubmed/16098810 Trends in Parasitology. 21(10): 476-81; 2005.] <br>
| |
| | |
| |}
| |
| | |
| <br style="clear:both" />
| |
