Saeij lab:Research: Difference between revisions

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==Identification of host genes and pathways that influence resistance or susceptibility to ''Toxoplasma''==
 
In addition to parasite strain differences, host genetic differences also determine the outcome of toxoplasmosis. We found that inflammatory pathways are differentially regulated in macrophages from susceptible and resistant mice. Using a genetic approach we have identified the mouse genomic regions that determine these differences and we are now in the position to identify the exact causative genes.


==Projects the lab is currently working on==
==Projects the lab is currently working on==

Revision as of 17:23, 4 January 2014

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Overview

Learn about our research at our website





Projects the lab is currently working on

   1. Pathogenesis: what properties make certain strains more virulent than others and what proteins are involved?
   2. How does Toxoplasma co-opt host-cell gene expression and how does this differ between strains?
   3. How does Toxoplasma modulate the NF-κB signaling pathway?
   4. How can we use Toxoplasma whole genome data to understand its population biology?
   5. What are the host genes and pathways that influence resistance or susceptibility to Toxoplasma?



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