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<biblio>
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[[Image:sackshot.jpg|thumb|right]]
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#Frost pmid=7915817
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Jon Sack, Ph.D.
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#Jaenecke pmid=8858584
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#Lawley pmid=12855161
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#Lessl pmid=8407818
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#Miller pmid=2993231
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#Martinez-Morales pmid=10559184
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#Wilkins pmid=12220405
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</biblio>
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<biblio>
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==Research interests==
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# <nowiki></nowiki>pmid=7915817
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Electrical signaling in living cells controls a wide variety of arguably important physiological processes such as feeling, thinking, and heartbeat. Electrophysiological signals are created by proteins known as ion channels, and modulating the behavior of ion channels will alter the processes they control.  The goal of my research program is to develop modulators selective for ion channel subtypes, to more precisely alter electrophysiological signals and identify channel subunits that generate native currents.  Establishing the molecular identity of voltage-gated potassium (Kv) channels has been a particularly challenging problem: mammalian channels arise from a family of more than 40 genes, and pore-forming subunits can assemble as heterotetramers. Despite substantial and enduring efforts, few modulators of Kv channel activity have been discovered that are highly selective between  channel subtypes.  This is perhaps due to a high degree of sequence conservation between subfamily members in functionally important transmembrane segments. Our research efforts seek to enhance the selectivity of channel modulators by covalent attachment to benign, yet well-targeted, biologics.
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</biblio>
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<SUP><!-- ## START CALENDAR COLUMN -->
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==Education==
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<LNCALENDAR></LNCALENDAR>
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<!--Include info about your educational background-->
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<!-- ## END CALENDAR COLUMN -->
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* Ph.D., Stanford University, Department of Biological Sciences
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* B.A., Reed College, Biochemistry
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==EXPANDING A TEMPLATE==
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==Institutional Affiliation==
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BASED ON [[TEMPLATE:FILEDESCRIPTION]]:
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<NOWIKI>
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{{FILEDESCRIPTION |
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NAME=NAME |
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DATE=20081012 |
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DESCRIPTION=HELLO I'M A DESCRIPTION |
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COMMENT=HELLO I'M A COMMENT
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}}</NOWIKI>
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==RESULT==
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{{FILEDESCRIPTION |NAME=NAME |DATE=20081012 |DESCRIPTION=HELLO I'M A DESCRIPTION |COMMENT=HELLO I'M A COMMENT}}
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{| {{TABLE|WIDTH: 73PX}}
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Assistant Professional Researcher
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| ALIGN="CENTER" STYLE="BACKGROUND:#F0F0F0;"|'''THIS'''
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| ALIGN="CENTER" STYLE="BACKGROUND:#F0F0F0;"|'''17'''
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| ALIGN="CENTER" STYLE="BACKGROUND:#F0F0F0;"|'''3.44'''
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| IS||29||2.33
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| A||39||5.31
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|-
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| TEST||44||45.3
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|-
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|}
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--[[USER:LINDENB|LINDENB]] 10:01, 8 DECEMBER 2008 (EST)
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Department of Neurobiology, Physiology & Behavior
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VOLUNTEER: JULIE NORVILLE
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College of Biological Sciences
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DATE: (SIGNED UP) JANUARY 26, 2009-(EXPECTS TO BE ACTIVE TILL) 2010
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BIO: A GRADUATE STUDENT AT MIT
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CONTACT: DIYOUTREACH AT GMAIL DOT COM
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(IF YOU DO NOT WANT THIS LISTED, YOU MAY PUT CONFIDENTIAL-CONTACT DIYOUTREACH AND SEND YOUR CONTACT INFO TO
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DIYOUTREACH AT GMAIL DOT COM)
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INTERESTS: DEVELOPING CHEAP BIOLOGICAL TOOLS AND TEACHING MATERIALS
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UNIVERSITY AFFILIATIONS: MIT (CURRENT), CALTECH (ALUMNA)
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GEOGRAPHICAL LOCATION: BOSTON AREA
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*'''[[USER:KENNY FREUNDLICH|KENNY FREUNDLICH]] 17:04, 6 APRIL 2009 (EDT)''':
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University of California
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BELOW IS ONE IMAGE.
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196 Briggs Hall
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LINK TO [[BIOTEST]]
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One Shields Avenue
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[[IMAGE:WELLESLEY-QUAD.JPEG‎]]
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Davis, California 95616
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[[IMAGE:ABSTRACT.PDF]]
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530.752.4131 tel
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530.754.6079 fax
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==TESTING WIKED==
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jsack (at) ucdavis (dot) edu
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X<SUP>2</SUP>
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<sub>sdfds
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<script src="http://pubget.com/widgetizer/render_js?q=stem%20cell%20RNA-Seq&count=5">  </script>  <noscript>  <a href="http://pubget.com/search?q=stem%20cell%20RNA-Seq">stem cell RNA-Seq</a> </noscript> 
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</sub>
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Revision as of 13:38, 7 March 2011

Jon Sack, Ph.D.

Research interests

Electrical signaling in living cells controls a wide variety of arguably important physiological processes such as feeling, thinking, and heartbeat. Electrophysiological signals are created by proteins known as ion channels, and modulating the behavior of ion channels will alter the processes they control. The goal of my research program is to develop modulators selective for ion channel subtypes, to more precisely alter electrophysiological signals and identify channel subunits that generate native currents. Establishing the molecular identity of voltage-gated potassium (Kv) channels has been a particularly challenging problem: mammalian channels arise from a family of more than 40 genes, and pore-forming subunits can assemble as heterotetramers. Despite substantial and enduring efforts, few modulators of Kv channel activity have been discovered that are highly selective between channel subtypes. This is perhaps due to a high degree of sequence conservation between subfamily members in functionally important transmembrane segments. Our research efforts seek to enhance the selectivity of channel modulators by covalent attachment to benign, yet well-targeted, biologics.

Education

  • Ph.D., Stanford University, Department of Biological Sciences
  • B.A., Reed College, Biochemistry

Institutional Affiliation

Assistant Professional Researcher

Department of Neurobiology, Physiology & Behavior

College of Biological Sciences

University of California

196 Briggs Hall

One Shields Avenue

Davis, California 95616

530.752.4131 tel

530.754.6079 fax

jsack (at) ucdavis (dot) edu

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