Sarah Carratt 4.12.11

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(New page: =Modeling!!= ==Gene Regulation and Modeling== *Focused on measuring RNA and modeling dynamic behavior of proteins that RNA spins off *High activity in RNA should mean high protein behavio...)
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Revision as of 12:41, 12 April 2011

Modeling!!

Gene Regulation and Modeling

  • Focused on measuring RNA and modeling dynamic behavior of proteins that RNA spins off
  • High activity in RNA should mean high protein behavior
  • Low activity in RNA should mean low protein behavior

Modeling in Network Construction

  • Qualitative, not just quantitative/numbers
  • Active genes working simultaneously → transcription factors
    • Define "simultaneously"
  • Database represents a model built through experiments and literature
  • Clustering and the modeling aspect
    • Define distance metric (this is what it means for two things to be close together)
  • Easily build matrix of closeness once distance is defined
  • Clustering is more subtle
    • time 1 graphed vs time 2...dot plot!
    • two+ clusters that are distinct, separate based on where they fall..."an art"
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