Sarah Carratt 4.12.11

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**Define "simultaneously"
**Define "simultaneously"
*Database represents a model built through experiments and literature
*Database represents a model built through experiments and literature
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*Clustering and the modeling aspect
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==Clustering==
**Define distance metric (this is what it means for two things to be close together)
**Define distance metric (this is what it means for two things to be close together)
*Easily build matrix of closeness once distance is defined
*Easily build matrix of closeness once distance is defined

Revision as of 11:44, 12 April 2011

Gene Regulation and Modeling

  • Focused on measuring RNA and modeling dynamic behavior of proteins that RNA spins off
  • High activity in RNA should mean high protein behavior
  • Low activity in RNA should mean low protein behavior

Modeling in Network Construction

  • Qualitative, not just quantitative/numbers
  • Active genes working simultaneously → transcription factors
    • Define "simultaneously"
  • Database represents a model built through experiments and literature

Clustering

    • Define distance metric (this is what it means for two things to be close together)
  • Easily build matrix of closeness once distance is defined
  • Clustering is more subtle
    • time 1 graphed vs time 2...dot plot!
    • two+ clusters that are distinct, separate based on where they fall..."an art"
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