User:Etienne Robillard/Notebook/Schiff base

From OpenWetWare

< User:Etienne Robillard | Notebook(Difference between revisions)
Jump to: navigation, search
(Add more concrete explanations about Yb(OTf)3/remote-activation catalysis of 1,2,3,4-tetrahydroisoquinolines...)
Current revision (17:26, 28 May 2015) (view source)
(Replacing page with '{{deleteme}}')
 
(61 intermediate revisions not shown.)
Line 1: Line 1:
-
=== Introduction to Schiff bases ===
+
{{deleteme}}
-
 
+
-
* Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of [http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation Schiff base formation]. [1]
+
-
* Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
+
-
** pharmacological intermediates (N-substituted heterocyclics)
+
-
** Nucleophilic carbonyl addition
+
-
** PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines
+
-
** Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
+
-
** 3-oxo-C6 HSL->lazy RNA polymerase riboswitch. [ENVZ]
+
-
** Light activated DNA delivery/toggle switch: How is that relevant to CES (ADA) and specifically CAMK2G? (H. sapiens CAP protein?)
+
-
 
+
-
=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion ===
+
-
 
+
-
* For the long story, see [[Phenylmethylamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (<font color="red">Micheal addition</font>) in presence of a organometal catalyst.
+
-
* assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
+
-
* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]
+
-
* tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable RNA polymerase repressor functions (LuxR) and AHL evidences in the design of <font color="red">Schiff base conjugated C6 (hexanoyl) psychochemicals to induce (lazy) light-activated RNA transcription and metabolism</font>. -[[User:Etienne_Robillard|ER]]
+
-
* Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -[[User:Etienne_Robillard|ER]]
+
-
 
+
-
=== References ===
+
-
 
+
-
# http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
+
-
# http://www.wikigenes.org/e/chem/e/7046.html
+

Current revision

It has been requested that this page be removed with restriction endonucleases.
Other articles for deletion are listed here.
Personal tools