User:Etienne Robillard/Notebook/Schiff base

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(Introduction to Schiff bases)
(Add more concrete explanations about Yb(OTf)3/remote-activation catalysis of 1,2,3,4-tetrahydroisoquinolines...)
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** pharmacological intermediates (N-substituted heterocyclics)
** pharmacological intermediates (N-substituted heterocyclics)
** Nucleophilic carbonyl addition
** Nucleophilic carbonyl addition
 +
** PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines
 +
** Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
 +
** 3-oxo-C6 HSL->lazy RNA polymerase riboswitch. [ENVZ]
 +
** Light activated DNA delivery/toggle switch: How is that relevant to CES (ADA) and specifically CAMK2G? (H. sapiens CAP protein?)
=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion ===
=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion ===
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* For the long story, see [[Phenylmethylamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst.  
+
* For the long story, see [[Phenylmethylamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (<font color="red">Micheal addition</font>) in presence of a organometal catalyst.  
* assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
* assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]
* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]]

Revision as of 09:53, 12 March 2013

Introduction to Schiff bases

  • Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of Schiff base formation. [1]
  • Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
    • pharmacological intermediates (N-substituted heterocyclics)
    • Nucleophilic carbonyl addition
    • PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines
    • Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
    • 3-oxo-C6 HSL->lazy RNA polymerase riboswitch. [ENVZ]
    • Light activated DNA delivery/toggle switch: How is that relevant to CES (ADA) and specifically CAMK2G? (H. sapiens CAP protein?)

Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion

  • For the long story, see Phenylmethylamine: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a enamine. See also Ethanamine. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst.
  • assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
  • Additional data is provided in EC 2.1.1.28 to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -ER
  • tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable RNA polymerase repressor functions (LuxR) and AHL evidences in the design of Schiff base conjugated C6 (hexanoyl) psychochemicals to induce (lazy) light-activated RNA transcription and metabolism. -ER
  • Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -ER

References

  1. http://chemwiki.ucdavis.edu/Organic_Chemistry/Organic_Chemistry_With_a_Biological_Emphasis/Chapter_11:_Nucleophilic_carbonyl_addition_reactions/Section_11.6:_Imine_(Schiff_base)_formation
  2. http://www.wikigenes.org/e/chem/e/7046.html
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