User:Etienne Robillard/Notebook/Schiff base
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** pharmacological intermediates (N-substituted heterocyclics) | ** pharmacological intermediates (N-substituted heterocyclics) | ||
** Nucleophilic carbonyl addition | ** Nucleophilic carbonyl addition | ||
| + | ** PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines | ||
| + | ** Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines) | ||
| + | ** 3-oxo-C6 HSL->lazy RNA polymerase riboswitch. [ENVZ] | ||
| + | ** Light activated DNA delivery/toggle switch: How is that relevant to CES (ADA) and specifically CAMK2G? (H. sapiens CAP protein?) | ||
=== Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion === | === Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion === | ||
| - | * For the long story, see [[Phenylmethylamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst. | + | * For the long story, see [[Phenylmethylamine]]: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a '''enamine'''. See also [[Ethanamine]]. Note that the C=N double bond is the result (product) of asymmetric synthesis (<font color="red">Micheal addition</font>) in presence of a organometal catalyst. |
* assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ? | * assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ? | ||
* Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]] | * Additional data is provided in [http://brenda-enzymes.org/php/result_flat.php4?ecno=2.1.1.28&Suchword=&organism%5B%5D=Homo+sapiens&show_tm=0 EC 2.1.1.28] to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -[[User:Etienne_Robillard|ER]] | ||
Revision as of 09:53, 12 March 2013
Introduction to Schiff bases
- Insert text here in scientifically acceptable way (ie: without grammar errors) to explain the functions and basics of Schiff base formation. [1]
- Present summarly the basic psychopharmacological aspects/functions of imine in a biological system .
- pharmacological intermediates (N-substituted heterocyclics)
- Nucleophilic carbonyl addition
- PS: Yb(OTf)3 route to 1,2,3,4-tetrahydroisoquinolines
- Micheal addition=>PS (Pictet-Spengler asymmetric synthesis of 1,2,3,4-tetrahydroisoquinolines)
- 3-oxo-C6 HSL->lazy RNA polymerase riboswitch. [ENVZ]
- Light activated DNA delivery/toggle switch: How is that relevant to CES (ADA) and specifically CAMK2G? (H. sapiens CAP protein?)
Formation of phenylmethylamine as the tautomeric form of a ethyl-methyl carbanion
- For the long story, see Phenylmethylamine: A nucleophilic Schiff base where the N-substituted anion is fused to a benzene ring (?) to yield a enamine. See also Ethanamine. Note that the C=N double bond is the result (product) of asymmetric synthesis (Micheal addition) in presence of a organometal catalyst.
- assert biological relevance of Parkinson disease [2] as the result of prolonged 1,2,3,4-tetrahydroisoquinolines derivatives absorption: A 2-phenylmethylamine-specific enatiomer ?
- Additional data is provided in EC 2.1.1.28 to confirm a solid link between Parkinson disease and novel tetrahydroisoquinolines derivatives. -- Check this. -ER
- tristable PD riboswitch abstrachachachatization: Check/verify the tri-stable RNA polymerase repressor functions (LuxR) and AHL evidences in the design of Schiff base conjugated C6 (hexanoyl) psychochemicals to induce (lazy) light-activated RNA transcription and metabolism. -ER
- Verify this lazy RNA polymerase function: 2ATP+CO2->Ph2CO<=>2(N+2(R)+OH) -ER
