Schwekendiek Lab

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==Lab Information==
==Lab Information==
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[http://sunny.molecularpharming.org Schwekendiek Lab Homepage]
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[[Schwekendiek_Lab_Inventory|Schwekendiek Lab Inventory]]
[[Schwekendiek_Lab_Inventory|Schwekendiek Lab Inventory]]

Revision as of 01:02, 18 November 2008

Who I am

Contents

Research Interests

Plant-made Phytopharmaceuticals

I am interested in developing sustainable and economic in planta production systems for pharmaceutically valuable natural products. Since a major focus of this work actually is on production, I am focussing on plants of broader economic importance for which extraction and processing systems are already in place. The hop plant (Humulus lupulus L.) is an interesting target because it perfectly meets this condition. Furthermore, although hops (the female flowers of the hop plant) is mainly used as an ingredient for beer, the hop plant has long been known for its medicinal uses. Interestingly, hops contain one of the most potent phytoestrogens known. Furthermore, highly active anti-cancer compounds have been identified in hops. Both compounds are produced in very low quantities in hops. Since they are not available from other plants, their limited occurrence hinders further exploitation. Therefore, the aims of my research are (a) to dissect the molecular pathways leading to production of these medicinally valuable compounds in hops, (b) to clone the corresponding genes and regulatory elements, and (c) to modify the biosynthetic routes in transgenic hop in order to increase their production in planta. I believe the successful development of transgenic hop with increased content of pharmaceutically active compounds could open up new high value markets for the hop industry.

Betalain Biosynthesis

Water soluble betalain pigments are interesting natural food colorants.

Undergraduate Research

Current Students

  • Pitra, Nicholi: Gland EST library, gene cloning
  • Hanson, Scott: Plant tissue culture and plant transformation, Temporary Immersion System
  • Koelling, Jared: Microbial strains and cultures, plasmid preparation


Past Students

  • Choi, Adi: Cloning a tyrosinase gene from pitaya fruit (Fall 2007)
  • Drake, Brenda: Development of a DNA extraction method for cactus fruit (Summer 2007)
  • Cunningham, Robert: Molecular biology and gene cloning (Spring 2007)

Lab Information

Schwekendiek Lab Homepage

Schwekendiek Lab Inventory

Schwekendiek Lab Color Codes

Schwekendiek Lab Procedures

Courses

840.119 - Introduction to Biotechnology (Fall 2006)
840.130 - Molecular Biology (Spring 2007)
840:153g - Recombinant DNA Techniques (Fall 2008)
820:215 - Corporate/Industrial Problem Solving (Spring 2008)

--Axel 21:33, 19 April 2008 (EDT)

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