Schwekendiek Lab

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Schwekendiek Lab - University of Northern Iowa<br>
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<li id="current">[[Schwekendiek_Lab| Home]]</li>
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<li>[[Axel:Schwekendiek_iGEM | Teaching]]</li>
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<li >[[Axel:Schwekendiek_Protocols|Protocols]]</li>
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<li >[[Axel:Schwekendiek_Tutorials | Tutorials]]</li>
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[[User:Axel|Who I am]]
[[User:Axel|Who I am]]
==Research Interests==
==Research Interests==
===Plant-made Phytopharmaceuticals===
===Plant-made Phytopharmaceuticals===
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[[Image:Hop.png|left]] In my lab we are interested in developing sustainable and economic ''in planta'' production systems for pharmaceutically valuable natural products. Since a major focus of this work actually is on production, we are focussing on plants of broader economic importance for which extraction and processing systems are already in place. We found the hop plant (''Humulus lupulus'' L.) being an interesting target because it perfectly meets this condition. Furthermore, although hops (the female flowers of the hop plant) is mainly used as an ingredient for beer, the hop plant - a member of the Cannabinaceae family - has long been known for its medicinal uses. Interestingly, hops contain one of the most potent phytoestrogens known from plants. Furthermore, highly active anti-cancer compounds have also been identified in hops. Both these compounds are produced in very low quantities in hops. Since they are not available from other plants, their limited occurence hinders further exploitation. Therefore, the aims of my research are (a) to dissect the molecular pathways leading to production of these medicinally valuable compounds in hops, (b) to clone the corresponding genes and regulatory elements, and (c) to modify the biosynthetic routes in transgenic hop in order to increase their production ''in planta''. I believe the successful development of transgenic hop with increased content of pharmaceutically active compounds could open up new high value markets for the hop industry.
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[[Image:Hop.png|left]] I am interested in developing sustainable and economic ''in planta'' production systems for pharmaceutically valuable natural products. Since a major focus of this work actually is on production, I am focussing on plants of broader economic importance for which extraction and processing systems are already in place. The hop plant (''Humulus lupulus'' L.) is an interesting target because it perfectly meets this condition. Furthermore, although hops (the female flowers of the hop plant) is mainly used as an ingredient for beer, the hop plant has long been known for its medicinal uses. Interestingly, hops contain one of the most potent phytoestrogens known. Furthermore, highly active anti-cancer compounds have been identified in hops. Both compounds are produced in very low quantities in hops. Since they are not available from other plants, their limited occurrence hinders further exploitation. Therefore, the aims of my research are (a) to dissect the molecular pathways leading to production of these medicinally valuable compounds in hops, (b) to clone the corresponding genes and regulatory elements, and (c) to modify the biosynthetic routes in transgenic hop in order to increase their production ''in planta''. I believe the successful development of transgenic hop with increased content of pharmaceutically active compounds could open up new high value markets for the hop industry.
===Betalain Biosynthesis===
===Betalain Biosynthesis===
Water soluble betalain pigments are interesting natural food colorants.
Water soluble betalain pigments are interesting natural food colorants.
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==Undergraduate Research==
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==Grad Students==
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===Current Students===
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*Pitra, Nicholi: Serial Analysis of Gene Expression in Hop (Humulus lupulus) glandular trichomes
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*Pitra, Nicholi: Gland EST library, gene cloning
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*Tiffany Walters: Betalain biosynthesis
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*Hanson, Scott: Plant tissue culture and plant transformation, Temporary Immersion System
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*Jessica Kettleson: Hop (Humulus lupulus) tissue culture and genetic engineering, Temporary Immersion System
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*Choi, Adi: Bioinformatics
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*Jared Koelling: EST-SSR Marker Development for Hops (Humulus lupulus L.)
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*Koelling, Jared: Microbial strains and cultures, plasmid preparation
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*Derek Stewart: Title to be determined
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*Drake, Brenda: Betalain Biosynthesis
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===Past Students===
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==Lab Information==
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*Cunningham, Robert: Molecular biology and gene cloning (Jan 2007 - May 2007)
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==Lab Inventory==
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[[Schwekendiek_Lab_Inventory|Schwekendiek Lab Inventory]]
[[Schwekendiek_Lab_Inventory|Schwekendiek Lab Inventory]]
[[Schwekendiek_Lab_Colorcodes|Schwekendiek Lab Color Codes]]
[[Schwekendiek_Lab_Colorcodes|Schwekendiek Lab Color Codes]]
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==Courses==
 
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[[840.119|840.119 - Introduction to Biotechnology (Fall)]]<BR>
 
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840.130 - Molecular Biology (Spring)<BR>
 
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840.153g - Recombinant DNA Techniques (Spring)
 
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--[[User:Axel|Axel]] 08:33, 22 March 2006 (EST)
 

Current revision

Schwekendiek Lab - University of Northern Iowa



Who I am

Research Interests

Plant-made Phytopharmaceuticals

I am interested in developing sustainable and economic in planta production systems for pharmaceutically valuable natural products. Since a major focus of this work actually is on production, I am focussing on plants of broader economic importance for which extraction and processing systems are already in place. The hop plant (Humulus lupulus L.) is an interesting target because it perfectly meets this condition. Furthermore, although hops (the female flowers of the hop plant) is mainly used as an ingredient for beer, the hop plant has long been known for its medicinal uses. Interestingly, hops contain one of the most potent phytoestrogens known. Furthermore, highly active anti-cancer compounds have been identified in hops. Both compounds are produced in very low quantities in hops. Since they are not available from other plants, their limited occurrence hinders further exploitation. Therefore, the aims of my research are (a) to dissect the molecular pathways leading to production of these medicinally valuable compounds in hops, (b) to clone the corresponding genes and regulatory elements, and (c) to modify the biosynthetic routes in transgenic hop in order to increase their production in planta. I believe the successful development of transgenic hop with increased content of pharmaceutically active compounds could open up new high value markets for the hop industry.

Betalain Biosynthesis

Water soluble betalain pigments are interesting natural food colorants.

Grad Students

  • Pitra, Nicholi: Serial Analysis of Gene Expression in Hop (Humulus lupulus) glandular trichomes
  • Tiffany Walters: Betalain biosynthesis
  • Jessica Kettleson: Hop (Humulus lupulus) tissue culture and genetic engineering, Temporary Immersion System
  • Jared Koelling: EST-SSR Marker Development for Hops (Humulus lupulus L.)
  • Derek Stewart: Title to be determined

Lab Information

Schwekendiek Lab Inventory

Schwekendiek Lab Color Codes

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