Silver: Publications

• Robinson, M.A., Park, S., Sun, Z.Y., Silver, P.A., Wagner,

G., and Hogle, J.M. Multiple conformations in the ligand-binding
site of the yeast nuclear pore targeting domain of Nup116p J.
Biol. Chem. 2005. Aug 16. Abstract

*Brodsky, A.S., Meyer, C.A., Hall, G., Swinburne, I.A., Keenan,
B.J., Liu, X.S., Fox, E.A., and., Silver, P.A. Genomic mapping
of RNA Polymerase II reveals sites of co-transcriptional regulation
in human cells. ‘‘‘Genome Biology. ‘‘‘2005. Jul 15:6(8): R64
Abstract

*McKee, A.E., Minet, E., Stern, C., Riahi, S., Stiles, C.D.,
and., Silver, P.A. A genome-wide in situ hybridization map of
RNA-binding proteins reveals anatomically restricted expression
in the developing mouse brain. ‘‘‘BMC Dev Biol. ‘‘‘2005. July
20;5(1):14 Abstract

*Carrol, J.S., Liu, X.S., C.R., Brodsky, A.S., Meyer, C.A.,
Li, W., Szary, A., Shao, W., Hesterman, E., Geistlinger, T.R.,
Fox, E.A., Silver, P.A., and Brown, M. Chromosome-wide mapping
of estrogen receptor binding reveals long-range combinatorial
regulation requiring forkhead proteins. ‘‘‘Cell. ‘‘‘2005. July
15;122(1):33-43 Abstract

*Park, S., Isaacson, R., Kim, H.T., Silver, P.A., and Wagner,
G. Ufd1 exhibits the AAA-ATPase fold with two distinct ubiquitin
interaction sites. ‘‘‘Structure (Camb) ‘‘‘2005. Jul; 13(7):995-1005. Abstract

*Casolari, J.M., Brown, C.R., Drubin, D.A., Rando, O.J., and
Silver, P.A. Developmentally induced changes in transcriptional
program alter spatial organization across chromosomes. ‘‘‘Genes
Dev. ‘‘‘2005. May 15;19(10):1188-98. Abstract

*Schroeder, F.C., Kau, T.R., Silver, P.A., and Clardy, J. The
psammaplysenes, specific inhibitors of FOXO1a nuclear export.
‘‘‘J Nat Prod ‘‘‘2005. Apr; 68(4):574-6. Abstract

*Devroe, E., Silver, P.A., and Engelman, A. HIV-1 incorporates
and proteolytically processes human NDR1 and NDR2 serien-threonine
kinases. ‘‘‘Virology ‘‘‘2005. Jan 5; 331(1):181-9. Abstract

*Hieronymus, H., and Silver, P.A. A systems view of mRNP biology.
‘‘‘Genes Dev. ‘‘‘2004. Dec 1,18(23):2845-60.Abstract

*Lu, R., Limon, A., Devroe, E., Cherepanov, P., Silver, P.A.,
and Engelman, Class II integrase mutants with changes in putative
nuclear localization signals are primarily blocked at a post-nuclear
entry step of human immunodeficiency virus type 1 replication.
‘‘‘J. Virol. ‘‘‘2004. Dec; 78(23):12735-46.Abstract

*Hieronymus, H., Yu, M.C., and Silver, P.A. Genome-wide mRNA
surveillance is coupled to the mRNA export. ‘‘‘Genes Dev. ‘‘‘2004.
Nov 1; 18(21):2652-62.Abstract

*Silver, P.A. and Way, Jeffrey. The potential for synthetic
biology. ‘‘‘The Scientist.’’’ 2004. Sept. 27; 18(18);30-1.<A
HREF="http://www.the-scientist.com/yr2004/sep/research2_040927.html">

</A>[silver%26way.pdf">Downloading PDF</A>

*Cherepanov, P., Devroe, E., Silver, P.A., and Engelman, A.
Identification of an evolutionarily-conserved domain in LEDGF/p75
that binds HIV-1 integrase. ‘‘‘J. Biol. Chem. ‘‘‘2004; Sept.
14 [Epub ahead of print]. Abstract

*Turlure, F., Devroe, E., Silver, P.A., and Engelman, A. Human
cell proteins and human immunodeficiency virus DNA integration.
‘‘‘Front Biosci. ‘‘‘2004; Sept. 1; 9:3187-208. Abstract

*Yu, M.C., Bachand F., McBride, A.E., Komili, S., Casolari,
J.M., and Silver, P.A. Arginine methyltransferase affects interactions
and recruitment of mRNA processing and export factors. ‘‘‘Genes
Dev.‘‘‘ 2004, Aug. 15. 18(16):2024-35. Abstract

*McKee A.E.. and Silver, P.A. REF-ereeing the cytoplasmic fate
of mRNA via nuclear export. ‘‘‘Dev Cell.‘‘‘ 2004. July
7; 23(13):2641-50.Abstract

*Bachand, F. and Silver, P.A. PRMT3 is a ribosomal protein
methyltransferase that affects the cellular levels of ribosomal
subunits. ‘‘‘EMBO J.‘‘‘ 2004. July 7; 23(13):2641-50.<A
HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15175657 Abstract]

*Casolari, J.M., Brown, C.R., Komili, S., West, J., Hieronymus,
H., and Silver, P.A. Genome-wide localization of the nuclear
transport machinery reveals coupling of transcriptional status
and nuclear organization. ‘‘‘Cell.‘‘‘ 2004. May 14; 117(4):427-39.<A
HREF="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=15137937 Abstract]

*Casolari, J.M. and Silver, P.A. Guardian at the gate: preventing
unspliced pre-mRNA export. ‘‘‘Trends Cell B iol.‘‘‘ 2004.
May, 14(5):222-5 Abstract

*Devroe, E., Erdjument-Bromage, H., Tempst, P., and Silver,
P.A. Human Mob proteins regulate the NDR1 and NDR2 serine-threonine
kinases. ‘‘‘JBC.‘‘‘ April 2, 2004. Abstract

*Devroe, E., and Silver, P.A. Therapeutic potential of retroviral
RNAi vectors ‘‘‘Expert Opin. Biol. Ther. ‘‘‘2004; 4(3):319-27.
[Devroe_EOBT.pdf">Downloading PDF</A>

*Kau, T.R., Way, J.C., and Silver, P.A. Nuclear transport and
cancer: from mechanism to intervention. ‘‘‘Nat. Rev. Cancer.
‘‘‘2004; Feb; 4(2):106-17. Abstract

*Jiang, Y., Minet, E., Zhang, Z., Silver, P.A., and Bai, M.
Modulation of interprotomer relationship is important for activation
of dimeric calcium-sensing receptor. ‘‘‘J. Biol. Chem. ‘‘‘2004.’’’

‘‘‘Abstract

*Kau, T.R., Schroeder, F., Ramazwamy, S., Wojciechowski, C.L.,
Zhao, J.J., Roberts, T.M., Clardy, J., Sellers, W.R., and Silver,
P.A. A Chemical genetic screen identifies inhibitors of regulated
nuclear export of a Forkhead transcription factor in PTEN deficient
tumor cells. ‘‘‘Cancer Cell. ‘‘‘2003; 4(6):463-76. Abstract

*Haggarty, S.J., Koeller, K.M., Kau, T.R., Silver, P.A., Roberge,
M., and Schreiber, S.L. Small molecule modulation of the human
chromatid decatenation checkpoint. ‘‘‘Chem. Biol. ‘‘‘2003; 10(12):1267-79.
Abstract

*Hitchcock, A.L., Auld, K., Gygi, S.P., and Silver, P.A. A
subset of membrane-associated proteins is ubiquitinated in response
to mutations in the endoplasmic reticulum degradation machinery.
‘‘‘Proc. Nat. Acad. Sci’’’.’’’ ‘‘‘2003, 100(22):12735-40.<A
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=14557538&dopt=Abstract">
Abstract</A>

*Devroe, E., Engelman, A., and Silver, P.A. Intracellular transport
of human immunodeficiency virus type 1 integrase ‘‘‘J. Cell.
Sci. ‘‘‘2003; 116(Pt21):4401-8. Abstract

*Brodsky, A.S,, Johnston, A.P,, Trau, M., and Silver, P.A.
Analysis of RNA-protein interactions by flow cytometry. ‘‘‘Curr.
Opin. Mol. Ther ‘‘‘2003; 5(3):235-40. Abstract

*Kau, T.R. and Silver, P.A. Nuclear transport as a target for
cell growth. ‘‘‘Drug Discov. Today. ‘‘‘2003; 8(2):78-85. <A
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12565010&dopt=Abstract Abstract]

*Hieronymus, H. and Silver, P.A. Genome-wide analysis of RNA-protein
interactions illustrates specificity of the mRNA export machinery.
‘‘‘Nat. Genet. ‘‘‘2003; 33(2):155-61. Abstract

*Beilharz T., Egan, B., Silver, P.A. Hofmann, K., and Lithgow,
T. Bipartite signals mediate subcellular targeting of tail-anchored
membrane protein in saccharomyces cerevisiae. ‘‘‘J. Biol. Chem.
‘‘‘2003; [epub ahead of print].[http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12514182&dopt=Abstract">
Abstract</A>

*Damelin, M. and Silver, P.A. In situ analysis of spatial relationships
between proteins of the nuclear pore complex. ‘‘‘Biophys J. ‘‘‘2002;
83(6): 3626-36.[http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12496130&dopt=Abstract">
Abstract</A>

*Brodsky, A.S. and Silver, P.A. A microbead-based system for
identifying and characterizing RNA-protein interactions by flow
cytometry. ‘‘‘Mol Cell Proteomics ‘‘‘2002; 1(12): 922-9. <A
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12543929&dopt=Abstract Abstract]

*Lei, E.P., Stern, C.A., Fahrenkrog, B., Krebber, H., Moy,
T.I., Aebi, U. and Silver, P.A., Sac3 is an mRNA export factor
that localizes to the cytoplasmic fibrils of the nuclear pore
complex. ‘‘‘Mol Biol Cell ‘‘‘2002; In Press.

*Lei, E. P. and Silver, P.A. Intron status and 3'-end formation
control cotranscriptional export of mRNA. ‘‘‘Genes Dev ‘‘‘2002;
16: 2761-2766. Abstract

*Limon A., Devroe, E., Lu, R., Ghory, H.Z., Silver, P.A., and
Engelman, A. Nuclear localization of human immunodeficiency virus
type 1 preintegration complexes (PICs): V165A and R166A are pleiotropic
integrase mutants primarily defective for integration, not PIC
nuclear import. ‘‘‘J Virol. ‘‘‘2002; 76(21): 10598-607.[http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12368302&dopt=Abstract">
Abstract</A>

*Devroe, E. and Silver, P.A. Retrovirus-delivered siRNA. ‘‘‘BMC
Biotechnol. ‘‘‘2002; 2(1): 15. Abstract

*Moy, T.I., and Silver, P.A. Requirements for the nuclear export
of the small ribosomal subunit. ‘‘‘J Cell Sci ‘‘‘2002; 115 (Pt
14): 2985-95.[http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12082158&dopt=Abstract">
Abstract</A>

*Damelin, M., Silver, P.A., and Corbett, A.H. Nuclear protein
transport. ‘‘‘Methods Enzymol. ‘‘‘2002; 351:587-607.

*Brodsky, A..S. and Silver, P.A. Identifying proteins that
affect mRNA localization in living cells. ‘‘‘Methods ‘‘‘2002;
26(2):151-5.

*Moy, T.I., Boettner, D., Rhodes, J.C., Silver, P.A., and Askew,
D.S. Identification of a role for Saccharomyces cerevisiae Cgr1p
in pre-rRNA processing and 60S ribosome subunit synthesis. ‘‘‘Microbiology
‘‘‘2002; 148 (Pt 4): 1081-1090. Abstract

*Damelin, M., Simon, I., Moy, T.I., Wilson, B., Komili, S.,
Tempst, P., Roth, F.P., Young, R.A., Carins, B.R., and Silver,
P.A. The genome-wide localization of Rsc9, a component of the
RSC chromatin-remodeling complex, changes in response to stress.
‘‘‘Mol Cell ‘‘‘2002; 9 (3): 563-73. Abstract

*Lei, E.P. and Silver, P.A. Protein and RNA export from the
nucleus. ‘‘‘Dev Cell. ‘‘‘2002; 2 (3): 261-72. Abstract

*Valentini, S.R., Casolari, J.M., Oliveira, C.C., Silver, P.A.
and McBride, A.E. Genetic interactions of yeast eukaryotic translation
initiation factor 5A (eIF5A) reveal connections to poly(A)-binding
protein and protein kinase C signaling. ‘‘‘Genetics ‘‘‘2002;
160 (2): 393-405. Abstract

*Hitchcock, A.L., Krebber, H., Frietze, S., Lin, A., Latterich,
M., and Silver, P.A. The conserved Npl4 protein complex mediates
proteasome-dependent membrane-bound transcription factor activation.
‘‘‘Mol Biol Cell ‘‘‘2001; 12 (10): 3226-3241. Abstract

*Lei, E.P., Krebber, H., and Silver, P.A. Messenger RNAs are
recruited for nuclear export during transcription. ‘‘‘Genes Dev.
‘‘‘2001; 15(14): 1771-1782. Abstract

*McBride, A.E. and Silver, P.A. State of the Arg: Protein methylation
at arginine comes of age. ‘‘‘Cell ‘‘‘2001; 106(1): 5-8.

*Tham, W., Wyithe, J.S., Ferrigno, P.K., Silver, P.A., and
Zakian, V.A. Localization of yeast telomeres to the nuclear periphery
is separable from transcriptional repression and telomere stability
functions. ‘‘‘Mol Cell ‘‘‘2001; 8(1): 189-199. Abstract

*Hood, J.K., Hwang, W.W., and Silver, P.A. The Saccharomyces
cerevisiae cyclin Clb2p is targeted to multiple subcellular locations
by cis- and trans-acting determinants. ‘‘‘J. Cell Sci. ‘‘‘2001;
114 (3): 589-597. Abstract

*Brodsky, A.S. and Silver, P.A. Pre-mRNA processing factors
are required for nuclear export. ‘‘‘RNA’’’ 2000; 6(12): 1737-1749.<A
HREF="http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11142374&dopt=Abstract Abstract]

*Colas, P., Cohen, B., Ferrigno, P.K., Silver, P.A., and Brent,
R. Targeted modification and transportation of cellular proteins.
‘‘‘Proc.Natl.Acad.Sci. USA ‘‘‘2000 Dec 5; 97(25): 13720-13725.
Abstract

*Weiss, V. H., McBride, A. E., Kim, H. K., Hogle, J. M., and
Silver, P. A. The structure and oligomerization of the yeast
arginine methyltransferase, Hmt1. ‘‘‘Nat. Struct. Biol.’’’ 2000;
7: 1165-1171. Abstract

*Stage-Zimmermann, T., Schmidt, U. and Silver, P.A. Factors
Affecting Nuclear Export of the 60S Ribosomal Subunit In Vivo.
‘‘‘Mol Biol Cell ‘‘‘2000 Nov;11(11):3777-3789. Abstract

*Krebber, H. and Silver, P.A. Directing proteins to nucleus
by fusion to nuclear localization signal tags. ‘‘‘Methods Enzymol’’’
2000;327:283-96. Abstract

*Prinz, W.A., Grzyb, L., Veenhuis, M., Kahana, J.A., Silver,
P.A. and Rapoport, T.A. Mutants affecting the structure of the
cortical endoplasmic reticulum in Saccharomyces cerevisiae. ‘‘‘J
Cell Biol ‘‘‘2000 Aug 7;150(3):461-74. Abstract

*Hood, J.K. and Silver, P.A. Diverse nuclear transport pathways
regulate cell proliferation and oncogenesis.’’’ Biochim Biophys
Acta’’’ 2000 Jul 31;1471(1):M31-41. Abstract

*Shen, E.C., Stage-Zimmermann, T., Chui, P., and Silver, P.A.
The yeast mRNA binding protein Npl3p interacts with the Cap Binding
Complex. ‘‘‘J. Biol. Chem.’’’ 2000 May 22. Abstract

*Ferrigno, P. and Silver, P.A. Polyglutamine expansions: proteolysis,
chaperones, and the dangers of promiscuity. ‘‘‘Neuron’’’ 2000
Apr;26(1):9-12. Abstract

*Hood, J.K., Casolari, J.M., and Silver, P.A. Nup2p is located
on the nuclear side of the nuclear pore complex and coordinates
Srp1p/importin-alpha export. ‘‘‘J. Cell Sci.’’’ 2000 Apr;113
(Pt 8):1471-80. Abstract

*Jones, A.L., Quimby, B.B., Hood, J.K., Ferrigno, P., Keshava,
P.H., Silver, P.A., and Corbett, A.H. SAC3 may link nuclear protein
export to cell cycle progression. ‘‘‘Proc. Natl. Acad. Sci. USA’’’
2000 Mar 28;97(7):3224-9. Abstract

*McBride, A.E., Weiss, V.H., Kim, H.K., Hogle, J.M., and Silver,
P.A. Analysis of the yeast arginine methyltransferase Hmt1p/Rmt1p
and its in vivo function. Cofactor binding and substrate interactions.
‘‘‘J. Biol. Chem. ‘‘‘2000 Feb 4;275(5):3128-36. Abstract

*Damelin, M. and Silver, P.A. Mapping interactions between
nuclear transport factors in living cells reveals pathways through
the nuclear pore complex. ‘‘‘Mol. Cell ‘‘‘2000; 5: 133-140.
Abstract

*Morehouse, H., Buratowski, R.M., Silver, P.A., and Buratowski,
S. The importin/karyopherin kap114 mediates the nuclear import
of TATA-binding protein. ‘‘‘Proc. Natl. Acad. Sci. U.S.A.’’’
1999; 96(22):12542-7.

*Ferrigno, P. and Silver, P.A. Regulated nuclear localization
of stress-responsive factors: how the nuclear trafficking of
protein kinases and transcription factors contributes to cell
survival. ‘‘‘Oncogene’’’ 1999; 18(45):6129-34.

*Moy, T.I. and Silver, P.A. Nuclear export of the small ribosomal
subunit requires the ran-GTPase cycle and certain nucleoporins.
‘‘‘Genes & Dev. ‘‘‘1999; 13(16):2118-33.

*Krebber, H., Taura, T., Lee, M.S., and Silver, P.A. Uncoupling
of the hnRNP Npl3p from mRNAs during the stress-induced block
in mRNA export. ‘‘‘Genes & Dev.’’’ 1999;13(15):1994-2004.

*Brodsky, A.S. and Silver, P.A. Nuclear transport HEATs up.
‘‘‘Nat. Cell. Biol.’’’ 1999;1(3):E66-E67.

*Zeng, X., Kahana, J.A., Silver, P.A., Morphew, M.K. McIntosh,J.R.,Fitch,
I.T., Carbon, J., and Saunders, W.S. Slk19p is a centromere protein
that functions to stabilize mitotic spindles. ‘‘‘J. Cell. Biol.’’’

1999;146(2):415-25.

*Defossez, P.A., Prusty, R., Kaeberlein, M., Lin, S.J., Ferrigno,
P., Silver, P.A., Keil, R.L., and Guarente, L. Elimination of
replication block protein Fob1 extends the life span of yeast
mother cells. ‘‘‘Mol. Cell ‘‘‘1999; 3(4):447-55.

*Hood, J.K. and Silver, P.A. In or out? Regulating nuclear
transport. ‘‘‘Curr. Opin. Cell. Biol. ‘‘‘1999;11(2):241-7.

*Valentini, S.R., Weiss, V.H., and Silver, P.A. Arginine methylation
and binding of Hrp1p to the efficiency element for mRNA 3'-end
formation. ‘‘‘RNA’’’ 1999; 5(2):272-80.

*Ferrigno, P. and Silver, P.A. Analysis of nuclear transport
in vivo. ‘‘‘Meth. Cell Biol. ‘‘‘1999;58:107-22.

*Seedorf, M., Damelin, M., Kahana, J.A., Taura, T., and Silver,
P.A. Interactions between a nuclear transporter and a subset
of nuclear pore complex proteins depend on Ran GTPase. ‘‘‘Mol.
Cell. Biol. ‘‘‘1999;19(2):1547-57.

*Hood, J.K. and Silver, P.A. Cse1p is required for export of
Srp1p/importin-alpha from the nucleus in Saccharomyces cerevisiae.
‘‘‘J. Biol. Chem. ‘‘‘1998; 273(52):35142-6.

*Silberstein, S., Schlenstedt, G., Silver, P.A., and Gilmore,
R. A role for the DnaJ homologue Scj1p in protein folding in
the yeast endoplasmic reticulum. ‘‘‘J. Cell. Biol.’’’ 1998;143(4):921-33.

*Ferrigno, P., Posas, F., Koepp, D., Saito, H., and Silver,
P.A. Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires
the importin beta homologs NMD5 and XPO1. ‘‘‘EMBO J.’’’ 1998;17(19):5606-14.

*Finley et al., Unified nomenclature for subunits of the yeast
proteasome regulatory particle. ‘‘‘TIBS ‘‘‘1998; 23:244-245.

*Taura, T., Krebber, H. and Silver, P.A. A member of the Ran
binding protein family, Yrb2p, is involved in NES dependent nuclear
protein export. ‘‘‘Proc. Natl. Acad. Sci. USA ‘‘‘1998; 95:7427-7432.

*Shen, E.C., Henry, M.F., Weiss, V.H., Valentini, S., Silver,
P.A., and Lee, M.S. Arginine methylation facilitates the nuclear
export of hnRNPs. ‘‘‘Genes & Dev. ‘‘‘1998; 12:679-691.

*Webb, C.D., Graumann, P., Kahana, J.A., Teleman, A., Silver,
P.A. and Losick, R. Use of time-lapse microscopy to visualize
rapid movement of the replication origin region of the chromosome
during the cell cycle in Bacillus subtilis. ‘‘‘Mol. Microbiol.
‘‘‘1998; 28:883-892.

*Kahana, J.A., Schlenstedt, G., Geiser, J.R., Evanchuck, D.M.,
Hoyt, A. and Silver, P.A. The yeast dynactin complex is involved
in partitioning the mitotic spindle between mother and daughter
cells during anaphase B. ‘‘‘Mol. Biol. Cell ‘‘‘1998; 9:1741-1756.

*Huyett, A., Kahana, J., Silver, P., Zeng, X., and Saunders,
W.S. Microtubule density controlled by antagonistic kinesin motors.
‘‘‘J. Cell Sci. ‘‘‘1998; 111:295-301.

*Vodicka, M.A., Koepp, D.M., Silver, P.A. and Emerman, M. HIV-1
Vpr interacts with the nuclear transport pathway to promote macrophage
infection. ‘‘‘Genes & Dev. ‘‘‘1998; 12:175-185.

*Kahana, J. and Silver, P.A. The uses of GFP in yeast. in ‘‘‘GFP:
Green Fluorescent Protein Strategies and Applications, ‘‘‘ed.
by M. Chalfie and S. Kain; John Wiley & Sons, Inc. 1998, in press.

*Scott, H.S., Antonarakis, S.E., Lalioti, M.D., Rossier, C.,
Silver, P.A., and Henry, M.F. Identification and characterization
of two putative human arginine methyltransferases (HRMT1L1 and
HRMT1L2). ‘‘‘Genomics ‘‘‘1998; 15:330-340.

*Koepp, D. and Silver, P.A. Nucleo-cytplasmic transport and
cell proliferation. ‘‘‘BBA Reviews in Cancer ‘‘‘1998; 1377:39-47.

*Taura, T., Schlenstedt, G. and Silver, P.A. Yrb2 is a nuclear
protein that interacts with Prp20p, a yeast Rcc1 homologue. ‘‘‘J.
Biol. Chem. ‘‘‘1997; 272:31877.

*Kessler, Henry, M., Shen, E., Zhao, J., Gross, S., Silver,
P., and Moore, C.L. Hrp1, an RNA binding protein that shuttles
between the nucleus and cytoplasm, is required for mRNA 3' end
formation in yeast. ‘‘‘Genes & Dev. ‘‘‘1997; 11:2545-2556.

*Lithgow, T., Cuezva, J.M., and Silver, P.A. Highways for delivery
to the mitochondria. ‘‘‘Trends in Biochemical Sciences ‘‘‘1997;
110-113.

*Corbett, A.H., Koepp, D.M., and Silver, P.A. Indirect immunofluorescence
in Saccharomyces cerevisiae. in ‘‘‘Cell Biology: a Laboratory
Manual ‘‘‘ed. by David Spector; Cold Spring Harbor Press, 1997.

*Silver, P.A. Scj1p. in ‘‘‘Guidebook to Molecular Chaperones
and Protein Folding Catalysts, ‘‘‘ed. by M.-J. Gething; Sambrook
& Tooze at Oxford University Press, 1997.

*Corbett, A. and Silver, P. Genetic analysis of nuclear transport.
‘‘‘Microbiology and Molecular Biology Reviews ‘‘‘1997; 61:193-211.

*Lee, M. and Silver, P.A. RNA movement from the nucleus. ‘‘‘Current
Opinion in Genetics & Development ‘‘‘1997; 212-219.

*Seedorf, M. and Silver, P. A. Importin/Karyopherin protein
family members required for mRNA export from the nucleus. ‘‘‘Proc.
Natl. Acad. Sci. USA ‘‘‘1997; 94:8590-8595.

*Clarkson, W.D., Corbett, A.H., Paschal, B.M., Kent, H.K.,
McCoy, A.J., Gerace, l., Silver, P.A., Stewart, M. Nuclear protein
import is descreased by engineered mutants of nuclear transport
factor 2 (NTF2) that do not bind GDP-Ran. ‘‘‘J. Mol. Biol. ‘‘‘1997;
272:716-730.

*Campbell, K.S., Mullane, K., Aksoy, I., Pipas, J.M., Silver,
P.A., Roberts, T.M., Schaffhausen, B.S., and DeCaprio, J.A. The
J-domain of SV40 large TAg mediates Hsc70 binding and viral DNA
replication. ‘‘‘Genes & Dev. ‘‘‘1997; 11:1098-1110.

*Wong, D.H., Corbett, A.H., Kent, H., Stewart, M. and Silver,
P.A. Interaction between the small GTPase Ran/Gsp1 and Ntf2 is
required for nuclear import. ‘‘‘Mol. Cell Biol. ‘‘‘1997; 17:3755-3767.

*Kahana, J. and Silver, P. Use of the A. victoria green fluorescent
protein to study protein dynamics in vivo. ‘‘‘Current Protocols
in Molecular Biology ‘‘‘1996; 9.7.22-9.7.28.

*Koepp, D. and Silver, P. A GTPase that controls nuclear trafficking:
Running the right way or walking RANdomly? ‘‘‘Cell ‘‘‘1996;
87:1-20.

*Corbett, A., Ferrigno, P., Henry, M., Kahana, J., Koepp, D.,
Lee, M., Nguyen, L., Schlenstedt, G., Seedorf, M., Shen, E.,
Taura, T. and Silver, P. Genetic analysis of macromolecular transport
across the nuclear envelope. (Proceedings from the Nobel Symposium)
‘‘‘Exp. Cell Res. ‘‘‘1996; 229:212-216.

*Koepp, D.M., Wong, D.H., Corbett, A.H., and Silver, P.A. Dynamic
localization of the nuclear import receptor and its interactions
with transport factors. ‘‘‘J. Cell Biol. ‘‘‘1996; 6:1163-1176.

*DeHoratius, C. and Silver, P.A. Nuclear transport defects
and nuclear envelope alterations are associated with mutation
of the Saccharomyces cerevisiae NPL4 gene. ‘‘‘Mol. Biol. Cell
‘‘‘1996; 7:1835-1855.

*Henry, M. and Silver, P. A novel arginine methyltransferase
(HMT1) modifies a poly(A) RNA-binding protein. ‘‘‘Mol. Cell.
Biol. ‘‘‘1996; 16:3668-3678.

*Haarer, K., Corbett, A.H., Kweon, Y., Petzold, A.S., Silver,
P.A. and Brown, S.S. SEC3 mutations are synthetically lethal
with profilin mutations and cause defects in diploid-specific
bud-site selection. ‘‘‘Genetics ‘‘‘1996; 144:495-510.

*Corbett, A.H. and Silver, P. A. The NTF2 gene encodes an essential
highly conserved protein that functions in nuclear transport
in vivo. ‘‘‘J. Biol. Chem. ‘‘‘1996; 271:18477-18484.

*Lee, M., Henry, M., and Silver, P. A protein that shuttles
between the nucleus and the cytoplasm is an important mediator
of RNA export. ‘‘‘Genes & Dev. ‘‘‘1996; 10:1233-1246.

*Henry, M., Borland, C., Bossie, M. and Silver, P. Potential
RNA binding proteins in Saccharomyces cerevisiae identified as
suppressors of temperature-sensitive mutations in NPL3. ‘‘‘Genetics
‘‘‘1996; 142:103-115.

*Koepp, D.M. and Silver, P. Rna1p, a GTPase activating protein,
plays a direct role in nuclear transport. ‘‘‘J. NIH Research
‘‘‘1995; 7:53-54.

*Schlenstedt, G., Wong, D., Koepp, D. and Silver, P. Mutants
in a yeast Ran binding protein are defective in nuclear transport.
‘‘‘EMBO J. ‘‘‘1995; 21:5367-5378.

*Corbett, A., Koepp, D., Schlenstedt, G., Lee, M., Hopper,
A., and Silver, P. Rna1p, a Ran/TC4 GTP-activating protein, is
required for nuclear import. ‘‘‘J. Cell Biol. ‘‘‘1995; 130:1-10.

*Kahana, J., Schnapp, B. and Silver, P. Kinetics of spindle
pole body separation in budding yeast. ‘‘‘Proc. Natl. Acad. Sci.
USA ‘‘‘1995; 92:9707-9711.

*Loeb, J.D.J., Schlenstedt, G., Pellman, D., Kornitzer, D.,
Silver, P.A. and Fink, G.R. A yeast nuclear import receptor homologue
required for mitosis. ‘‘‘Proc. Natl. Acad. Sci. USA ‘‘‘1995;
92:7647-7651.

*Schlenstedt, G., Harris, S., Risse, B., Lill, R. and Silver,
P. A yeast DnaJ homologue, Scj1, can function in the endoplasmic
reticulum with BiP/Kar2p via a conserved domain that specifies
interaction with Hsp70s. ‘‘‘J. Cell Biol. ‘‘‘1995; 129:979-988.

*Schlenstedt, G., Saavedra, C., Loeb, J., Cole, C. and Silver,
P. The GTP-bound form of the yeast Ran/TC4 homologue blocks bi-directional
transport across the nuclear envelope. ‘‘‘Proc. Natl. Acad. Sci.
USA ‘‘‘1995; 92:225-229.

*Flach, J., Bossie, M., Vogel, J., Corbett, A., Jinks, T.,
Willins, D., and Silver, P.A. A yeast RNA binding protein shuttles
between the nucleus and the cytoplasm. ‘‘‘Mol. Cell Biol. ‘‘‘1994;
14:8399-407.

*Osborne, M. A., Schlenstedt, G. Jinks, T. and Silver, P. Nuf2,
a spindle pole body associated protein required for nuclear division
in yeast. ‘‘‘J. Cell Biology ‘‘‘1994; 125:853-66.

*Osborne, M. and Silver, P. Nucleocytoplasmic transport in
the yeast Saccharomyces cerevisiae. ‘‘‘Annual Review of Biochemistry
‘‘‘1993; 62:219-54.

*Silver, P. and Way, J. Eukarytotic DnaJ homologues and the
specificity of hsp70 action. ‘‘‘Cell ‘‘‘1993; 74:1-3.

*Schlenstedt, G. , Hurt, E., Doye, V. and Silver, P. Reconstitution
of nuclear protein transport with semi-intact yeast cells. ‘‘‘J.
Cell Biology ‘‘‘1993; 123:785-98.

*Kurihara, T. and Silver, P. Suppression of a sec63 mutation
identifies a novel component of the ER translocation apparatus.
‘‘‘Mol. Biol. Cell ‘‘‘1993; 4:919-30.

*Nelson, M., Kurihara, T. and Silver, P. Extragenic suppressors
of mutations in the cytoplasmic C-terminus of Sec63 define five
genes in S. cerevisiae. ‘‘‘Genetics ‘‘‘1993; 134:159-73.

*Stochaj, U., Bossie, M., van Zee, K. and Silver, P. Analysis
of conserved binding proteins for nuclear localization sequences.
‘‘‘J. Cell Science ‘‘‘1993; 104:89-95.

*Kurihara, T. and Silver, P. DnaJ homologs and protein transport.
in ‘‘‘Membrane Biogenesis and Protein Targeting, ‘‘‘ed. W. Neupert
and R. Lill; Elsevier Science Publishers, 1992; 309-27.

*Bossie, M., Barcelo, G., Dehoratius, C., and Silver, P. A
mutant nuclear protein with similarity to RNA binding proteins
interferes with nuclear import in yeast. ‘‘‘Mol. Biol. Cell ‘‘‘1992;
3:875-93.

*Stochaj, U. and Silver, P. A conserved phosphoprotein that
specfically binds nuclear localization sequences is involved
in nuclear import. ‘‘‘J. Cell Biology ‘‘‘1992; 117:473-82.

*Silver, P. How proteins enter the nucleus. ‘‘‘Cell ‘‘‘1991;
64:489-97.

*Blumberg, H. and Silver, P. A yeast protein containing two
separated zinc fingers is required for normal cell growth. ‘‘‘Gene
‘‘‘1991; 107:101-10.

*Stochaj, U., Osborne, M., Kurihara, T. and Silver, P. A yeast
protein that binds nuclear localization sequences: Purification,
localization and antibody inhibition of binding activity. ‘‘‘J.
Cell Biology ‘‘‘1991; 113:1243-54.

*Blumberg, H. and Silver, P. SCJ1, a DNAJ homologue that alters
protein sorting in yeast. ‘‘‘Nature ‘‘‘1991; 349:627-30.