Silver: RNA Dynamics

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(Dynamics of RNAs)
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(Dynamics of RNAs)
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===Dynamics of RNAs===
The importance of RNAs in regulation of cell determination and disease continues to grow. We study the dynamics of RNAs including co-transcriptional alternative splicing and transport,  and the relative efficiency of pre-mRNA processing and its impact on noise in gene expression. ([[User: IanSwinburne |Ian Swinburne]]). We use a combination of genetic, biochemical and novel genomic and imaging approaches to study RNA dynamics on a systems-wide level in both model organisms (yeast and fly) and human cells, eg ([[User: NatalieGilks |Natalie Gilks]], [[User: OonaJohnstone |Oona Johnstone]]  and [[User: MichaelMoore |Michael Moore]]). We have generated a spatial and temporal map of the expression of all RNA-binding proteins in mammalian neural development ([[User: AdrienneMckee |Adrienne Mckee]]).  One goal is to decode the way that proteins recognize RNA throughout the genome.

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