|
|
| (5 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| ===Dynamics of RNAs===
| |
|
| |
|
| The importance of RNAs in regulation of cell determination and disease continues to grow. We study the dynamics of RNAs including co-transcriptional alternative splicing and transport, and the relative efficiency of pre-mRNA processing and its impact on noise in gene expression. ([[User: IanSwinburne |Ian Swinburne]]). We use a combination of genetic, biochemical and novel genomic and imaging approaches to study RNA dynamics on a systems-wide level in both model organisms (yeast and fly) and human cells, eg ([[User: NatalieGilks |Natalie Gilks]], [[User: OonaJohnstone |Oona Johnstone]], [[User: GuillaumeAdelmant |Guillaume Adelmant]] and [[User: MichaelMoore |Michael Moore]]). We have generated a spatial and temporal map of the expression of all RNA-binding proteins in mammalian neural development ([[User: AdrienneMckee |Adrienne Mckee]]). One goal is to decode the way that proteins recognize RNA throughout the genome.
| |
