Silver: RNA Dynamics

Dynamics of RNAs

The importance of RNAs in regulation of cell determination and disease continues to grow. We study the dynamics of RNAs including co-transcriptional alternative splicing and transport, and the relative efficiency of pre-mRNA processing and its impact on noise in gene expression. (Ian Swinburne). We use a combination of genetic, biochemical and novel genomic and imaging approaches to study RNA dynamics on a systems-wide level in both model organisms (yeast and fly) and human cells, eg (Natalie Gilks, Oona Johnstone, Guillaume Adelmant and Michael Moore). We have generated a spatial and temporal map of the expression of all RNA-binding proteins in mammalian neural development (Adrienne Mckee). One goal is to decode the way that proteins recognize RNA throughout the genome.