Silver: RNA Dynamics

Dynamics of RNAs

The importance of RNAs in regulation of cell determination and disease continues to grow. We study the dynamics of RNAs including co-transcriptional alternative splicing and transport, and the relative efficiency of pre-mRNA processing and its impact on noise in gene expression. (Ian Swinburne). We use a combination of genetic, biochemical and novel genomic and imaging approaches to study RNA dynamics on a systems-wide level in both model organisms (yeast and fly) and human cells, eg (Natalie Gilks, Oona Johnstone, Guillaume Adelmant and Michael Moore). We have generated a spatial and temporal map of the expression of all RNA-binding proteins in mammalian neural development (Adrienne Mckee). One goal is to decode the way that proteins recognize RNA throughout the genome.

The mouse RNA binding protein data is posted here.