Small molecule binding by SPR

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Drug-like small organic molecules often do not dissolve well in water. To profile binding of small molecules with SPR, small concentration (<10%) of DMSO is used to improve drug solubility.
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A common technique is to add DMSO solution of drug to the aqueous buffer <cite>karlsson1</cite>.
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Dielectric properties of DMSO and water are significantly different and significant mismatch of {{SPR:RU}}
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<biblio>
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#karlsson1 pmid=10821711
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<biblio>
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[[Category:SPR]]
[[Category:SPR]]

Revision as of 17:51, 7 April 2008

Drug-like small organic molecules often do not dissolve well in water. To profile binding of small molecules with SPR, small concentration (<10%) of DMSO is used to improve drug solubility. A common technique is to add DMSO solution of drug to the aqueous buffer [1].

Dielectric properties of DMSO and water are significantly different and significant mismatch of RU

  1. Frostell-Karlsson A, Remaeus A, Roos H, Andersson K, Borg P, Hämäläinen M, and Karlsson R. . pmid:10821711. PubMed HubMed [karlsson1]
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