Sobeck Lab

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(POSTDOC WANTED!)
Current revision (14:44, 23 May 2013) (view source)
 
(33 intermediate revisions not shown.)
Line 1: Line 1:
{{Sobeck}}
{{Sobeck}}
-
<div style="padding: 20px; width: 720px; border: 7px solid #00416A;">
+
<div style="padding: 20px; width: 1000px; border: 7px solid #00416A;">
-
<div style="padding: 11px; width: 680px; border: 3px solid #00FF00;">
+
<div style="padding: 11px; width: 940px; border: 3px solid #00FF00;">
-
<div style="padding: 1px; width: 660px; border: 3px solid #DDDDFF;">
+
<div style="padding: 1px; width: 870px; border: 3px solid #DDDDFF;">
<div style="border:1px solid orange;background-color:#FFFACD;padding:1px;">
<div style="border:1px solid orange;background-color:#FFFACD;padding:1px;">
----
----
-
==Lab News==
 
-
''Our PCR's are fail-proof :)''
+
===WELCOME TO THE SOBECK LAB===
 +
We are interested in signaling pathways that contribute to the maintenance of genomic stability in our cells and prevent cancer susceptibility in humans. We are studying DNA repair pathways
 +
that are activated during the S-phase of the cell cycle when chromosomes replicate.
 +
Our research centers on the  Fanconi Anemia (FA) and Breast Cancer associated (BRCA1, BRCA2) repair pathways that are suspected have crucial functions in DNA repair and cell cycle checkpoint activation during S-phase. Humans born with mutations in FA genes have a highly elevated risk to develop certain types of cancers including acute myeloid leukemia (AML) and various types of solid tumors. Acquired mutations and silencing of FA genes have been found in different cancers in the general population and the FA genes are thus considered "caretakers" of our genome. Our goal is to understand the molecular functions of the FA/BRCA proteins (currently 15 FA/BRCA genes are known) and to elucidate how these proteins communicate with other members of the DNA damage response network to control and suppress genomic instability.
 +
Our lab uses a combination of human cell-based assays and extracts prepared from eggs of the African clawed frog,'' Xenopus laevis''. These extracts are naturally cell-cycle synchronized and able to replicate and repair DNA in a test tube, providing us with a cell-free system that can be manipulated in many ways and that allows us to ask specific questions about functions of individual FA/BRCA proteins during the DNA damage response.
-
Even Alex' plants can come back from the dead....
 
-
'''HAPPY 1010!!! ''' [[image:Frog10.gif]]
+
   
-
==<font color="red"> POSTDOC WANTED! </font>==
 
-
We are currently inviting applications for a Postdoctoral Associate Position to investigate mechanisms of genomic instability and cancer susceptibility.
+
[[Image:Sobeck GROUPsmaller.jpg]]
-
Our lab is part of the Masonic Comprehensive Cancer Center and focuses on elucidating functions of Fanconi Anemia (FA) and Breast Cancer Associated Proteins in the context of cellular caretaker networks. We utilize biochemical assays in Xenopus laevis cell-free egg extracts and human cell systems to identify novel pathway players and functionally and structurally characterize Fanconi Anemia/BRCA proteins.
 
-
We seek enthusiastic candidates that have a solid background in Molecular Biology/ Biochemistry and enjoy being part of a highly motivated research team. A specific interest and expertise in DNA repair and replication would be ideal. Our research team works in an open lab structure that nurtures interactions with neighboring laboratories studying fundamental questions in cancer research and the DNA damage response.
+
 
-
The start date is negotiable but ideal start will be Spring 2010.
+
 
-
Interested? Please send a short statement of your research interests, complete curriculum vitae, and the names and contact information of at least two references by e-mail to asobeck@umn.edu with "Postdoc Position Sobeck Lab" as subject line.
+
'''May 2013 (left to right): Maya Raghunandan, Dan Stroik, Alex Sobeck, Jung-Eun Yeo, Indrajit Chaudhury, Sarah Riman, Niki Sathish Kumar'''
 +
 
 +
===Lab News===
 +
 
 +
 
 +
 
 +
----
 +
<span style="color:blue">!! Mark your calendars for the Fanconi Anemia Research Fund Symposium from October 24-27, 2013 in Houston, Texas</span>
 +
  [[image:Frog10.gif]]
==Useful links==
==Useful links==
*[[OpenWetWare:Welcome|Introductory tutorial]]
*[[OpenWetWare:Welcome|Introductory tutorial]]
*[[Help|OpenWetWare help pages]]
*[[Help|OpenWetWare help pages]]

Current revision

Home/Research        Contact        Lab Members        Publications        Talks        Protocols        Internal       



WELCOME TO THE SOBECK LAB

We are interested in signaling pathways that contribute to the maintenance of genomic stability in our cells and prevent cancer susceptibility in humans. We are studying DNA repair pathways that are activated during the S-phase of the cell cycle when chromosomes replicate.

Our research centers on the Fanconi Anemia (FA) and Breast Cancer associated (BRCA1, BRCA2) repair pathways that are suspected have crucial functions in DNA repair and cell cycle checkpoint activation during S-phase. Humans born with mutations in FA genes have a highly elevated risk to develop certain types of cancers including acute myeloid leukemia (AML) and various types of solid tumors. Acquired mutations and silencing of FA genes have been found in different cancers in the general population and the FA genes are thus considered "caretakers" of our genome. Our goal is to understand the molecular functions of the FA/BRCA proteins (currently 15 FA/BRCA genes are known) and to elucidate how these proteins communicate with other members of the DNA damage response network to control and suppress genomic instability.

Our lab uses a combination of human cell-based assays and extracts prepared from eggs of the African clawed frog, Xenopus laevis. These extracts are naturally cell-cycle synchronized and able to replicate and repair DNA in a test tube, providing us with a cell-free system that can be manipulated in many ways and that allows us to ask specific questions about functions of individual FA/BRCA proteins during the DNA damage response.




Image:Sobeck GROUPsmaller.jpg



May 2013 (left to right): Maya Raghunandan, Dan Stroik, Alex Sobeck, Jung-Eun Yeo, Indrajit Chaudhury, Sarah Riman, Niki Sathish Kumar

Lab News


!! Mark your calendars for the Fanconi Anemia Research Fund Symposium from October 24-27, 2013 in Houston, Texas

 image:Frog10.gif

Useful links

Personal tools