Sobeck Lab

From OpenWetWare

(Difference between revisions)
Jump to: navigation, search
(2 intermediate revisions not shown.)
Line 1: Line 1:
{{Sobeck}}
{{Sobeck}}
-
<div style="padding: 20px; width: 720px; border: 7px solid #00416A;">
+
<div style="padding: 20px; width: 1000px; border: 7px solid #00416A;">
-
<div style="padding: 11px; width: 680px; border: 3px solid #00FF00;">
+
<div style="padding: 11px; width: 940px; border: 3px solid #00FF00;">
-
<div style="padding: 1px; width: 660px; border: 3px solid #DDDDFF;">
+
<div style="padding: 1px; width: 870px; border: 3px solid #DDDDFF;">
<div style="border:1px solid orange;background-color:#FFFACD;padding:1px;">
<div style="border:1px solid orange;background-color:#FFFACD;padding:1px;">
Line 15: Line 15:
Our lab uses a combination of human cell-based assays and extracts prepared from eggs of the African clawed frog,'' Xenopus laevis''. These extracts are naturally cell-cycle synchronized and able to replicate and repair DNA in a test tube, providing us with a cell-free system that can be manipulated in many ways and that allows us to ask specific questions about functions of individual FA/BRCA proteins during the DNA damage response.
Our lab uses a combination of human cell-based assays and extracts prepared from eggs of the African clawed frog,'' Xenopus laevis''. These extracts are naturally cell-cycle synchronized and able to replicate and repair DNA in a test tube, providing us with a cell-free system that can be manipulated in many ways and that allows us to ask specific questions about functions of individual FA/BRCA proteins during the DNA damage response.
-
 
-
 
-
 
Line 25: Line 22:
 +
[[Image:Sobeck GROUPsmaller.jpg]]
-
 
+
'''May 2013 (left to right): Maya Raghunandan, Dan Stroik, Alex Sobeck, Jung-Eun Yeo, Indrajit Chaudhury, Sarah Riman, Niki Sathish Kumar'''
-
 
+
-
[[Image: [[Image:Sobeck lab FA core 2013.jpg]]]]
+
-
'''In this picture (left to right): Rose Kantor, Charlene Fares, Brittany Feia, Archana Sareen, Jordan Becker, Indrajit Chaudhury, Nicki Adams, Alex Sobeck'''
+
===Lab News===
===Lab News===
-
 
-
 
-
==<span style="color:green">Postdoctoral position available starting January 2013:</span> ==
 
-
 
-
This position will work on elucidating novel functional interactions between FA proteins and other DNA repair enzymes under normal and perturbed cellular conditions. We are seeking a highly dedicated individual with a solid background in mechanisms of DNA replication and repair, and a strong interest in dissecting the complex DNA damage response mechanisms that protect our cells from mutagenic influences.
 
-
 
-
Please email your CV, contact information of 3 references and a concise statement of your research experience to:
 
-
Alex Sobeck, asobeck@umn.edu.
 
-
 
-
 
----
----
-
<span style="color:blue">!! Mark your calendars for the Fanconi Anemia Research Fund Symposium from September 27-30, 2012 in Denver, Colorado</span>
+
<span style="color:blue">!! Mark your calendars for the Fanconi Anemia Research Fund Symposium from October 24-27, 2013 in Houston, Texas</span>
   [[image:Frog10.gif]]
   [[image:Frog10.gif]]

Revision as of 13:44, 23 May 2013

Home/Research        Contact        Lab Members        Publications        Talks        Protocols        Internal       



WELCOME TO THE SOBECK LAB

We are interested in signaling pathways that contribute to the maintenance of genomic stability in our cells and prevent cancer susceptibility in humans. We are studying DNA repair pathways that are activated during the S-phase of the cell cycle when chromosomes replicate.

Our research centers on the Fanconi Anemia (FA) and Breast Cancer associated (BRCA1, BRCA2) repair pathways that are suspected have crucial functions in DNA repair and cell cycle checkpoint activation during S-phase. Humans born with mutations in FA genes have a highly elevated risk to develop certain types of cancers including acute myeloid leukemia (AML) and various types of solid tumors. Acquired mutations and silencing of FA genes have been found in different cancers in the general population and the FA genes are thus considered "caretakers" of our genome. Our goal is to understand the molecular functions of the FA/BRCA proteins (currently 15 FA/BRCA genes are known) and to elucidate how these proteins communicate with other members of the DNA damage response network to control and suppress genomic instability.

Our lab uses a combination of human cell-based assays and extracts prepared from eggs of the African clawed frog, Xenopus laevis. These extracts are naturally cell-cycle synchronized and able to replicate and repair DNA in a test tube, providing us with a cell-free system that can be manipulated in many ways and that allows us to ask specific questions about functions of individual FA/BRCA proteins during the DNA damage response.




Image:Sobeck GROUPsmaller.jpg



May 2013 (left to right): Maya Raghunandan, Dan Stroik, Alex Sobeck, Jung-Eun Yeo, Indrajit Chaudhury, Sarah Riman, Niki Sathish Kumar

Lab News


!! Mark your calendars for the Fanconi Anemia Research Fund Symposium from October 24-27, 2013 in Houston, Texas

 image:Frog10.gif

Useful links

Personal tools