Sobeck Lab

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We are interested in deciphering signaling pathways that contribute to the maintenance of genomic stability in our cells. We are specifically investigating DNA repair pathways that are activated during the S-phase of the cell cycle when chromosomes replicate. Our current focus are the Fanconi Anemia (FA) and Breast Cancer associated (BRCA1, BRCA2) repair pathways that are suspected to act at the crossroads of DNA replication, repair, and cell cycle checkpoint activation. Our lab uses Xenopus laevis cell-free egg extracts that are naturally cell-cycle synchronized and replication competent to study roles of FA and BRCA pathway members during the DNA damage response.

Image:Sobeck lab overview FA pathway.jpg

In this picture (left to right): Rose Kantor, Charlene Fares, Brittany Feia, Archana Sareen, Jordan Becker, Indrajit Chaudhury, Nicki Adams, Alex Sobeck

Lab News

!! Mark your calendars for the Fanconi Anemia Research Fund Symposium from Oct 20-23 in Barcelona Spain !!


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