Sreenath:aml

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== Purpose ==
== Purpose ==
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To understand the behavior of signaling mechanism in hematopoietic disorders, in particular Acute Myelogenous Leukemia (AML) using Complex Systems Biology and a data rich flow cytometry approach.
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To understand the behavior of the signaling mechanism in hematopoietic disorders, in particular Acute Myelogenous Leukemia (AML) using Complex Systems Biology and a data rich flow cytometry approach.
== Meeting ==
== Meeting ==

Revision as of 16:56, 17 May 2007

CASE Complex Systems Biology Center

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AML Project

Purpose

To understand the behavior of the signaling mechanism in hematopoietic disorders, in particular Acute Myelogenous Leukemia (AML) using Complex Systems Biology and a data rich flow cytometry approach.

Meeting

The AML Systems Biology group meets every Friday, with alternating locations in the Wolstein conference room (WRB 3-522) and the OLIN conference room (OLIN 408). Meeting time in WRB is 9:00 to 10:00 am, while meeting time in OLIN is 9:30 to 10:30 am.

Participants

Faculty

Professor James 'Jake' Jacobberger (Hematology/Oncology), Director of the Cytometry Core Facility

Sree N. Sreenath (Electrical Engineering and Computer Science)

Other

R. Michael Sramkoski, Manager of the Cytometry Core Facility

Yehong Huong

Radina P. Soebiyanto

Michael C. Weis

Jayant Avva

Arielle Kanters

Akshai Singh

Papers being discussed

All papers are available on the group's internal account.

Disruption of Differentiation in Human Cancer: AML Shows the Way Nature Reviews Cancer, 2003 Daniel Tenen

The Role of FLT3 in Hematopoietic Malignancies Nature Reviews Cancer, 2003 Derek L. Stirewalt and Jerald P. Radich

Cross-talk and decision making in MAP kinase pathways Nature Genetics Megan N McClean, Areez Mody, James R Broach and Sharad Ramanathan

Compartmental Architecture and Dynamics of Hematopoiesis PLoS ONE, 2007

David Dingli, Arne Taulsen, Jorge M. Pacheco
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