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== Purpose == | == Purpose == | ||
To understand the behavior of signaling mechanism in hematopoietic disorders, in particular Acute Myelogenous Leukemia (AML) using Complex Systems Biology and a data rich flow cytometry approach. | To understand the behavior of the signaling mechanism in hematopoietic disorders, in particular Acute Myelogenous Leukemia (AML) using Complex Systems Biology and a data rich flow cytometry approach. | ||
== Meeting == | == Meeting == | ||
Revision as of 13:56, 17 May 2007
CASE Complex Systems Biology Center
AML Project
Purpose
To understand the behavior of the signaling mechanism in hematopoietic disorders, in particular Acute Myelogenous Leukemia (AML) using Complex Systems Biology and a data rich flow cytometry approach.
Meeting
The AML Systems Biology group meets every Friday, with alternating locations in the Wolstein conference room (WRB 3-522) and the OLIN conference room (OLIN 408). Meeting time in WRB is 9:00 to 10:00 am, while meeting time in OLIN is 9:30 to 10:30 am.
Participants
Faculty
Professor James 'Jake' Jacobberger (Hematology/Oncology), Director of the Cytometry Core Facility
Sree N. Sreenath (Electrical Engineering and Computer Science)
Other
R. Michael Sramkoski, Manager of the Cytometry Core Facility
Yehong Huong
Radina P. Soebiyanto
Michael C. Weis
Jayant Avva
Arielle Kanters
Akshai Singh
Papers being discussed
All papers are available on the group's internal account.
Disruption of Differentiation in Human Cancer: AML Shows the Way Nature Reviews Cancer, 2003 Daniel Tenen
The Role of FLT3 in Hematopoietic Malignancies Nature Reviews Cancer, 2003 Derek L. Stirewalt and Jerald P. Radich
Cross-talk and decision making in MAP kinase pathways Nature Genetics Megan N McClean, Areez Mody, James R Broach and Sharad Ramanathan
Compartmental Architecture and Dynamics of Hematopoiesis PLoS ONE, 2007 David Dingli, Arne Taulsen, Jorge M. Pacheco
