The purpose of this page is to post the recent articles that we in the Stephanopoulos group review in our nearly-weekly literature review presentations. Sometimes the presenter focuses on a particular paper, and sometimes the roughly one-hour talk gives a brief overview of an important series of related papers.
27 April 2006: Curt Fischer
Curt presented a recent PNAS article  which explicated a newly-discovered operon in E. coli. This operon encodes a previously unreported pathway for uracil degradation, which ends in the excretion of 3-hydroxypropionic acid in the medium. He also briefly mentioned two other recent high-profile papers on nitrogen metabolism--one reported the genome sequence of a anaerobic ammonium oxidizing bacterium and hypthesized the full structure of this metabolic pathway , and the other presents laborious and careful analysis carbon utilization of non-thermophilic archaea living in medium-depth oceanic waters. These bacteria fix inorganic carbon and oxidize nitrogen, and are probably major players in the global nitrogen cycle.
Error fetching PMID 16598256:
Error fetching PMID 16614070:
- Error fetching PMID 16540542:
- Error fetching PMID 16598256:
- Error fetching PMID 16614070:
4 May 2006: Joel Forrest Moxley
Joel gave an excellent overview of several landmark papers about new tools for high-throughput data collection in systems biology. The papers were made possible by advances in tiling DNA microarrays, protein arrays, and automated yeast transformation and colony characterization.
Error fetching PMID 16527929:
Error fetching PMID 16319894:
Error fetching PMID 16455487:
Error fetching PMID 16554755:
- Error fetching PMID 16122420:
- Error fetching PMID 16527929:
- Error fetching PMID 16319894:
- Error fetching PMID 16455487:
- Error fetching PMID 16554755:
18 May 2006: José O. Alemán
José gave a brief overview of two papers looking at insulin resistance from a perspective of cellular and animal experiments. The first uses cellular and animal experiments addressing reactive oxygen species' role in insulin resistance, while the second carefully dissects insulin signaling in the liver to tease divergent metabolic control of glucose an lipid metabolism.
Error fetching PMID 16679292:
- Error fetching PMID 16612386:
- Error fetching PMID 16679292:
back to the Stephanopoulos Lab home page