Stephanopoulos:Projects
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= <font style="color:maroon">Research</font> = | = <font style="color:maroon">Research</font> = | ||
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components: | Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components: | ||
| - | + | # '''The modification of biochemical pathways inside cells''', and | |
| - | + | # '''The rigorous evaluation of the resulting cellular phenotypes.''' | |
Our most recent research has been focused on the following topics: | Our most recent research has been focused on the following topics: | ||
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Production of biochemicals in E. coli | '''Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals''']] |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Inverse Metabolic Engineering | '''Inverse Metabolic Engineering''']] |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:gTME | '''gTME''']] |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Flux Determination | '''Flux Determination''']] |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Hepatocyte Physiology | '''Hepatocyte Physiology''']] |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Metabolomics | '''Metabolomics''']] |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Rational Drug Design | '''Rational Drug Design''']] |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Systems Biology | '''Systems Biology''']] |
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methods, many of which have also become areas of research for our group: | methods, many of which have also become areas of research for our group: | ||
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Bioinformatics and Systems Biology | '''Bioinformatics and Systems Biology''']] - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies. |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Methods for intracellular flux determination | '''Methods for intracellular flux determination''']] - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements. |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:DNA microarrays | '''DNA microarrays''']] - We have developed full genome microarrays for ''Synechocystis'' Sp., and partial microarrays for ''C. glutamicum'', ''E. coli'', and the mouse genomes. |
| - | :* [[Stephanopoulos | + | :* [[Stephanopoulos:Bioreaction network analysis | '''Bioreaction network analysis''']] |
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ResearchOur research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
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