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<align=left><h1 style="color:maroon">Research</h1></align>
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Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
<b>a)</b> the modification of biochemical pathways inside cells and
<b>b)</b> the rigorous evaluation of the resulting cellular phenotypes.
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Our most recent research has been focussed on the following topics:
<br>
                <ul>
<li><b><a href="Biochemicals.shtml">Metabolic Engineering of <i>E.Coli</i>
                for the production of biochemicals.</b></a>


<li><b><a href="Inverse.shtml">Inverse Metabolic Engineering</b></a>
# '''The modification of biochemical pathways inside cells''', and
# '''The rigorous evaluation of the resulting cellular phenotypes.'''
 
Our most recent research has been focused on the following topics:
 
:* [[Stephanopoulos:Production of biochemicals in E. coli | '''Metabolic Engineering of <i>E.Coli</i> for the production of biochemicals''']]


<li><b><a href="gTME.shtml">gTME</b></a>
:* [[Stephanopoulos:Inverse Metabolic Engineering | '''Inverse Metabolic Engineering''']]
 
                <li><b><a href="Flux.shtml">Flux Determination</b></a>
:* [[Stephanopoulos:gTME | '''gTME''']]
 
:* [[Stephanopoulos:Flux Determination | '''Flux Determination''']]
 
:* [[Stephanopoulos:Hepatocyte Physiology | '''Hepatocyte Physiology''']]
 
:* [[Stephanopoulos:Metabolomics | '''Metabolomics''']]
 
:* [[Stephanopoulos:Rational Drug Design | '''Rational Drug Design''']]
 
:* [[Stephanopoulos:Systems Biology | '''Systems Biology''']]
 
 
To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
 
:* [[Stephanopoulos:Bioinformatics and Systems Biology | '''Bioinformatics and Systems Biology''']] - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.


<li><b><a href="Hepatocyte.shtml">Hepatocyte Physiology</b></a>
:* [[Stephanopoulos:Methods for intracellular flux determination | '''Methods for intracellular flux determination''']] - Fluxes are determined by material balancing, NMR fine spectra analysis and GC-MS measurements.


<li><b><a href="Metabolomics.shtml">Metabolomics</b></a>
:* [[Stephanopoulos:DNA microarrays | '''DNA microarrays''']] - We have developed full genome microarrays for ''Synechocystis'' Sp., and partial microarrays for ''C. glutamicum'', ''E. coli'', and the mouse genomes.  


<li><b><a href="SysBio.shtml">Systems Biology</b></a>
:* [[Stephanopoulos:Bioreaction network analysis | '''Bioreaction network analysis''']]
                </ul>
                <br>
            To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
                <ul>
                <p>
                <li>
                <b><a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a></b> - Our group was
one of the first to realize the importance of computational tools for handling the
large volume of data generated by microarrays and other technologies.
                <li>
<b><a href="Fluxes.shtml">Methods for intracellular flux determination</a></b>
                - Fluxes are determined by material balancing, NMR fine spectra analysis and
GC-MS measurements.
                <li>
                <b><a href="Microarray.shtml">DNA microarrays</a></b> - We have developed full
genome microarrays for <i>Synechocystis</i> Sp., and partial microarrays for
                <i>C. glutamicum</i>, <i>E. coli</i>, and the mouse genomes.
                <li>
                <b><a href="BioReactor.shtml">Bioreaction network analysis.</a></b>
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      <font color="maroon"><tt>Address</tt></font><br>
      <small>
Massachusetts Institute of Technology<br>
Department of Chemical Engineering<br>
Cambridge, MA 02139<br>
Room 56-469
      </small>
  </td>
  <td align="center" width="250" valign="top">
      <small>
<a href="http://www.mit.edu">MIT</a> | <a href="/wiki/Stephanopoulos_Lab">HOME</a><br>
Last Modified:<br>Monday, July 10th, 2006 - by <a href="Adrian.shtml">afi</a>.
      </small>
      <br>
      <font color="#990000"><tt>gnswebpage-www@mit.edu</tt></font>
  </td>
  <td align="right" width="250" valign="top">
      <font color="#990000"><tt>Telephones</tt><br></font>
      <small>
office | 617.258.0398<br>
lab | 617.253.6591<br>
lab | 617.258.0349<br>
lab | 617.253.6521<br>
fax | 617.253.3122<br>
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Latest revision as of 15:30, 17 July 2007

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Research

Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:

  1. The modification of biochemical pathways inside cells, and
  2. The rigorous evaluation of the resulting cellular phenotypes.


Our most recent research has been focused on the following topics:


To accomplish the above goals we make use of a diverse array of scientific tools and methods, many of which have also become areas of research for our group:

  • Bioinformatics and Systems Biology - Our group was one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
  • DNA microarrays - We have developed full genome microarrays for Synechocystis Sp., and partial microarrays for C. glutamicum, E. coli, and the mouse genomes.
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