Stephanopoulos:Projects: Difference between revisions
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<align=left><h1 style="color:maroon">Research</h1></align> | |||
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Our research is focused on Metabolic Engineering - the improvement of cellular | Our research is focused on Metabolic Engineering - the improvement of cellular | ||
properties, using modern genetic tools. This field encompasses two important components: | properties, using modern genetic tools. This field encompasses two important components: | ||
<b>a)</b> the modification of biochemical pathways inside cells and <b>b)</b> the rigorous | <b>a)</b> the modification of biochemical pathways inside cells and <b>b)</b> the rigorous | ||
evaluation of the resulting cellular phenotypes. In recent years our group has investigated | evaluation of the resulting cellular phenotypes. | ||
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In recent years our group has investigated | |||
the following topics: | the following topics: | ||
<ul> | <ul> | ||
Revision as of 07:20, 12 July 2006
<html> <align=left><h1 style="color:maroon">Research</h1></align> </html>
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components: a) the modification of biochemical pathways inside cells and b) the rigorous evaluation of the resulting cellular phenotypes.
<html>
In recent years our group has investigated
the following topics:
<ul>
<li><b><a href="Coryne.shtml">Aminoacid biosynthesis in
<i>Corynebacterium glutamicum</i>.</b></a>
<li><b><a href="Rhodo.shtml">Indene bioconversion in <i>Rhodococcus </i>Sp.</b></a>
<li><b><a href="Synecho.shtml">CO<sub>2</sub> fixation and product synthesis by the cyanobacterium <i>Synechocystis</i> Sp.</b></a>
<li><b><a href="Diabetes.shtml">Elucidating type II diabetes by
linking the expression and metabolic phenotypes of hepatoma and hepatocyte
cells.</b></a>
</ul>
To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
<ul>
<p>
<li>
<b><a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a></b> - Our group was
one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
<li>
<b><a href="Fluxes.shtml">Methods for intracellular flux determination</a></b>
- Fluxes are determined by material balancing, NMR fine spectra analysis and
GC-MS measurements.
<li>
<b><a href="Microarray.shtml">DNA microarrays</a></b> - We have developed full
genome microarrays for <i>Synechocystis</i> Sp., and partial microarrays for
<i>C. glutamicum</i>, <i>E. coli</i>, and the mouse genomes.
<li>
<b><a href="BioReactor.shtml">Bioreaction network analysis.</a></b>
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