Stephanopoulos:Projects
<html> <align=left><h1 style="color:maroon">Research</h1></align> </html>
Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components: a) the modification of biochemical pathways inside cells and b) the rigorous evaluation of the resulting cellular phenotypes.
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Our most recent research has been focussed on the following topics:
<ul>
<li><b><a href="Biochemicals.shtml">Metabolic Engineering of <i>E.Coli</i>
for.</b></a> the production of biochemicals.
<li><b><a href="Inverse.shtml">Inverse Metabolic Engineering</b></a>
<li><b><a href="gTME.shtml">gTME</b></a>
<li><b><a href="Flux.shtml">Flux Determination</b></a>
<li><b><a href="Hepatocyte.shtml">Hepatocyte Physiology</b></a>
<li><b><a href="Metabolomics.shtml">Metabolomics</b></a>
<li><b><a href="SysBio.shtml">Systems Biology</b></a>
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To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
<ul>
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<li>
<b><a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a></b> - Our group was
one of the first to realize the importance of computational tools for handling the large volume of data generated by microarrays and other technologies.
<li>
<b><a href="Fluxes.shtml">Methods for intracellular flux determination</a></b>
- Fluxes are determined by material balancing, NMR fine spectra analysis and
GC-MS measurements.
<li>
<b><a href="Microarray.shtml">DNA microarrays</a></b> - We have developed full
genome microarrays for <i>Synechocystis</i> Sp., and partial microarrays for
<i>C. glutamicum</i>, <i>E. coli</i>, and the mouse genomes.
<li>
<b><a href="BioReactor.shtml">Bioreaction network analysis.</a></b>
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