Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
a) the modification of biochemical pathways inside cells and
b) the rigorous evaluation of the resulting cellular phenotypes.
Our most recent research has been focussed on the following topics:
To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
Bioinformatics and Systems Biology - Our group was
one of the first to realize the importance of computational tools for handling the
large volume of data generated by microarrays and other technologies.
Methods for intracellular flux determination
- Fluxes are determined by material balancing, NMR fine spectra analysis and
DNA microarrays - We have developed full
genome microarrays for Synechocystis Sp., and partial microarrays for
C. glutamicum, E. coli, and the mouse genomes.
Bioreaction network analysis.
Massachusetts Institute of Technology
Department of Chemical Engineering
Cambridge, MA 02139
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