Our research is focused on Metabolic Engineering - the improvement of cellular properties, using modern genetic tools. This field encompasses two important components:
a) the modification of biochemical pathways inside cells and
b) the rigorous evaluation of the resulting cellular phenotypes.
Our most recent research has been focused on the following topics:
Metabolic Engineering of E.Coli for the production of biochemicals
Inverse Metabolic Engineering
gTME
Flux Determination
Hepatocyte Physiology
Metabolomics
Systems Biology
To accomplish the above goals we make use of a diverse array of scientific tools and
methods, many of which have also become areas of research for our group:
<a href="Bioinfo.shtml">Bioinformatics and Systems Biology</a> - Our group was
one of the first to realize the importance of computational tools for handling the
large volume of data generated by microarrays and other technologies.
<a href="Fluxes.shtml">Methods for intracellular flux determination</a>
- Fluxes are determined by material balancing, NMR fine spectra analysis and
GC-MS measurements.
<a href="Microarray.shtml">DNA microarrays</a> - We have developed full
genome microarrays for Synechocystis Sp., and partial microarrays for
C. glutamicum, E. coli, and the mouse genomes.
